CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000807
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vinculin 
Protein Synonyms/Alias
  
Gene Name
 Vinc 
Gene Synonyms/Alias
 CG3299 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
106YSGPARKKLIEGSRGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane (By similarity). 
Sequence Annotation
 REPEAT 258 362 1.
 REPEAT 371 470 2.
 REGION 258 470 2 X repeats.
 MOD_RES 774 774 Phosphothreonine.  
Keyword
 Actin-binding; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 961 AA 
Protein Sequence
MPVFHTKTIE SILDPVAQQV SRLVILHEEA EDGNAMPDLS RPVQVVSAAV ANLVKVGRDT 60
INSSDDKILR QDMPSALHRV EGASQLLEEA SDMLRSDPYS GPARKKLIEG SRGILQGTSS 120
LLLCFDESEV RKIIQECKRV LDYLAVAEVI NTMEQLVQFL KDLSPCLSKV HREVGAREKE 180
LTHQVHSEIL VRCLEQVKTL APILICSMKV YIHIVEQQGR GAEEAAENRN YLAARMSDEL 240
QEIIRVLQLT TYDEDTSELD NLTVLKKLSN AISNKMEQAN EWLSNPYALR GGVGEKALRQ 300
VIDNATEISE RCLPQDSYPI RKLADEVTAM ANTLCELRQE GKGQSPQAES LVRGIRDRMG 360
ELKSLVHQAV LGVDKAGVQQ TAHTIQGRLE QAVKWLQHPE INDGGLGERA INLIVEEGRK 420
VAEGCPGHQK AEIQQLCDEV ERLKRQAAGS GPAAKQAAKQ LTQKLYELKA AIQNALVNRI 480
VQDFMDVSTP LKQFTEAVLQ PEGTPGREQN FNQKSNNLQA FSDRASKTSR MVAAGGACGN 540
KKIAEILLSS AAQVDSLTPQ LISAGRIRMN YPGSKAADEH LQNLKQQYAD TVLRMRTLCD 600
QATDPADFIK TSEEHMQVYA KLCEDAIHAR QPQKMVDNTS NIARLINRVL LVAKQEADNS 660
EDPVFTERLN AAANRLERSL PAMVGDAKLV ATNIADPAAA AAWKNSFQRL LGDVREVRDA 720
IAPPQPPPLP TSLPPPIPEL SALHLSNQNA ERAPPRPPLP REGLAPVRPP PPETDDEDEG 780
VFRTMPHANQ PILIAARGLH QEVRQWSSKD NEIIAAAKRM AILMARLSEL VLSDSRGSKR 840
ELIATAKKIA EASEDVTRLA KELARQCTDR RIRTNLLQVC ERIPTIGTQL KILSTVKATM 900
LGAQGSDEDR EATEMLVGNA QNLMQSVKET VRAAEGASIK IRSDQTSNRL QWVRRQPWYQ 960
Y 961 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005925; C:focal adhesion; ISS:FlyBase.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; ISS:FlyBase.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0007016; P:cytoskeletal anchoring at plasma membrane; ISS:FlyBase.
 GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase. 
Interpro
 IPR017997; Vinculin.
 IPR006077; Vinculin/catenin.
 IPR000633; Vinculin_CS. 
Pfam
 PF01044; Vinculin 
SMART
  
PROSITE
 PS00663; VINCULIN_1
 PS00664; VINCULIN_2 
PRINTS
 PR00806; VINCULIN.