UniProt Accession

 RAB7A_MOUSE; P51150 

Genbank Protein ID

 X89650; AK005004; BC004597; BC086793 

Genbank Nucleotide ID

 CAA61797.1; BAB23738.1; AAH04597.1; AAH86793.1 

Protein Name

 Ras-related protein Rab-7a 

Protein Synonyms/Alias

  

Gene Name

 Rab7a 

Gene Synonyms/Alias

 Rab7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
31	LMNQYVNKKFSNQYK	acetylation	[1]
38	KKFSNQYKATIGADF	ubiquitination	[2]
126	PFVVLGNKIDLENRQ	ubiquitination	[2]
191	NEFPEPIKLDKNDRA	ubiquitination	[2]
194	PEPIKLDKNDRAKAS	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). 

Sequence Annotation

 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 125 128 GTP (By similarity).
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 72 72 Phosphoserine.
 MOD_RES 207 207 Cysteine methyl ester (By similarity).
 LIPID 205 205 S-geranylgeranyl cysteine (By
 LIPID 207 207 S-geranylgeranyl cysteine (By  

Keyword

 Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Lysosome; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 207 AA 

Protein Sequence

Gene Ontology

 GO:0097208; C:alveolar lamellar body; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005770; C:late endosome; IDA:MGI.
 GO:0005764; C:lysosome; ISO:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; IEA:Compara.
 GO:0007174; P:epidermal growth factor catabolic process; IEA:Compara.
 GO:0006886; P:intracellular protein transport; TAS:MGI.
 GO:0090383; P:phagosome acidification; ISS:UniProtKB.
 GO:0090385; P:phagosome-lysosome fusion; ISS:UniProtKB.
 GO:0006622; P:protein targeting to lysosome; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.