CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027671
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 aceF 
Gene Synonyms/Alias
 STM0153 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
316PAAKAEGKSEFAENDacetylation[1]
Reference
 [1] Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.
 Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, Zhao GP.
 Science. 2010 Feb 19;327(5968):1004-7. [PMID: 20167787] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Lipoyl; Pyruvate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 629 AA 
Protein Sequence
MAIEIKVPDI GTDEVEITEI LVKVGDKVEA EQSLITVEGD KASMEVPSPQ AGVVKEIKVS 60
VGDKTETGAL IMIFDSAEGA ADAAPAKAEE KKEAAPAAAP AAAAAKDVHV PDIGSDEVEV 120
TEVMVKVGDT VEAEQSLITV EGDKASMEVP APFAGTVKEI KVNTGDKVST GSLIMVFEVA 180
GEAGAAAPAK AEAAPAAAAP AAATGVKDVN VPDIGGDEVE VTEVMVKVGD KVTAEQSLIT 240
VEGDKASMEV PAPFAGTVKE IKISTGDKVK TGSLIMVFEV EGAAPAAAPA KQEAAAPAPA 300
AKAEKPAAPA AKAEGKSEFA ENDAYVHATP LIRRLAREFG VNLAKVKGTG RKGRILREDV 360
QAYVKDAIKR AERAPAAAGG GIPGMLPWPK VDFSKFGEVE EVELGRIQKI SGANLSRNWV 420
MIPHVTHFDK TDITDLEAFR KQQNAEAEKR KLDVKYTPVV FIMKAVAAAL EQMPRFNSSL 480
SEDGQRLTLK KYINIGVAVD TPNGLVVPVF KDVNKKSVTE LSRELTTISK KARDGKLTAG 540
EMQGGCFTIS SIGGLGTTHF APIVNAPEVA ILGVSKSAME PVWNGKEFVP RLMMPISLSF 600
DHRVIDGADG ARFITIINNM LSDIRRLVM 629 
Gene Ontology
 GO:0045254; C:pyruvate dehydrogenase complex; IEA:InterPro.
 GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:InterPro. 
Interpro
 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR001078; 2-oxoacid_DH_actylTfrase.
 IPR006256; AcTrfase_Pyrv_DH_cplx.
 IPR000089; Biotin_lipoyl.
 IPR023213; CAT-like_dom.
 IPR004167; E3-bd.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF00198; 2-oxoacid_dh
 PF00364; Biotin_lipoyl
 PF02817; E3_binding 
SMART
  
PROSITE
 PS50968; BIOTINYL_LIPOYL
 PS00189; LIPOYL 
PRINTS