UniProt Accession

 FABR_ECOLI; P0ACU5; P27307; Q2M8Q8 

Genbank Protein ID

 X66026; U00006; U00096; AP009048 

Genbank Nucleotide ID

 CAA46823.1; AAC43069.1; AAC76945.2; BAE77348.1 

Protein Name

 HTH-type transcriptional repressor FabR 

Protein Synonyms/Alias

  

Gene Name

 fabR 

Gene Synonyms/Alias

 yijC; b3963; JW3935 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
192	LQLRMISKGAYYWYR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. 

Sequence Annotation

 DOMAIN 10 70 HTH tetR-type.
 DNA_BIND 33 52 H-T-H motif (By similarity).  

Keyword

 Complete proteome; Cytoplasm; DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:HAMAP.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009057; Homeodomain-like.
 IPR001647; HTH_TetR.
 IPR015893; Tet_transcr_reg_TetR-like_C.
 IPR023764; Tscrpt_reg_HTH_FabR. 

Pfam

 PF00440; TetR_N 

SMART

  

PROSITE

 PS01081; HTH_TETR_1
 PS50977; HTH_TETR_2 

PRINTS