UniProt Accession

 BABA1_MOUSE; Q3UI43; Q8C5Q8; Q99JU2; Q9CTJ4 

Genbank Protein ID

 AK003366; AK077402; AK078265; AK147083; BC005692 

Genbank Nucleotide ID

 BAB22740.1; BAC36785.1; BAC37197.1; BAE27663.1; AAH05692.1 

Protein Name

 BRISC and BRCA1-A complex member 1 

Protein Synonyms/Alias

 Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex 

Gene Name

 Babam1 

Gene Synonyms/Alias

 Merit40; Nba1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
237	FSLTEPMKKMFQCPY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component (By similarity). 

Sequence Annotation

 REGION 99 302 VWFA-like.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 33 33 Phosphoserine (By similarity).
 MOD_RES 53 53 Phosphoserine (By similarity).  

Keyword

 Acetylation; Chromatin regulator; Complete proteome; Cytoplasm; DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0070531; C:BRCA1-A complex; ISS:UniProtKB.
 GO:0070552; C:BRISC complex; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; ISS:UniProtKB.
 GO:0031572; P:G2 DNA damage checkpoint; ISS:UniProtKB.
 GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.
 GO:0070536; P:protein K63-linked deubiquitination; ISS:UniProtKB.
 GO:0010212; P:response to ionizing radiation; ISS:UniProtKB. 

Interpro

 IPR026126; BABAM1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS