| Tag | Content |
|---|
| CPLM ID | CPLM-021122 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-protein ligase E3B |
Protein Synonyms/Alias | |
Gene Name | Ube3b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 429 | PQTVLPVKSLLKRAF | ubiquitination | [1] | | 624 | HWLRRDLKPGVLFQE | ubiquitination | [1] | | 753 | DPALNLFKTTSGDER | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). |
Sequence Annotation | DOMAIN 29 58 IQ.
DOMAIN 704 1070 HECT.
ACT_SITE 1038 1038 Glycyl thioester intermediate (By
MOD_RES 421 421 Phosphoserine (By similarity). |
Keyword | Complete proteome; Ligase; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1070 AA |
Protein Sequence | MFTVSQTSRA WFIDRARQAR EERLVQKERE RSAVTIQALV RSFLCRRRLH RDIRKEIDEF 60
FSADESGSSK RSALCIFKIA RRLLFICKTT EDSERLEKLC RSILNSMDAE NEPKVWYVSL 120
ALSKDLTLLW IKQIKSILWH CCELLGQLKP EILQDSRLIT LYLTMLVTFT DTSTWKILRG 180
KGESLRPALN HICANIMGHL NQRGLYSVLQ VLLTRGLARP RPCLSKGMLT AAFSLALRPV 240
VAAQFSDNLM RPFIIHVMSV PALVAHLSTV APERLGVLES HDMLRKFIVF LRDRDRCRDA 300
CESLEGCHTL CLMGNLLHLG SLSLRLLEEE MDGFVSALTQ MLCYCQKYVA QKKSNLTHWH 360
PVLGWFSQPV DYGLNDSMYL ITKQLQFLWA VPLIRILFSD ILSRKLLEHA EPAPVQPQPS 420
SPQTVLPVKS LLKRAFQKSA SVRNILRPVG GRRVDSAEVR KVCNICVLYQ TSLTTLTQIR 480
LQILTGLTYL DDLLPKLWAF ICELGPHGGL KLFLECLNND TGESKQLLAM LMLFCDCSRH 540
LITILDDIEV YEEQISFKLE ELVTISSFLN SFVFKMIWDG IVENAKGETL ELFQSVHGWL 600
MVLYERDCRR RFAPEDHWLR RDLKPGVLFQ ELDKDRRRAQ LVLQHIPHVV PHKNRVLLFR 660
NMVIKEKEKL GLVETSSASP HVTHITIRRS RMLEDGYEQL RQLSQHAMKG VIRVKFVNDL 720
GVDEAGIDQD GVFKEFLEEI IKRVFDPALN LFKTTSGDER LYPSPTSYIH ENYLQLFEFV 780
GKMLGKAVYE GIVVDVPFAS FFLSQMLGHH HSVFYSSVDE LPSLDSEFYK NLTSIKRYDG 840
DIADLGLTLS YDEDVMGQLV CHELVPGGKT IPVTDENKIS YIHLMAHFRM HTQIKNQTAA 900
LISGFRSIIK PEWIRMFSTP ELQRLISGDN AEIDLEDLKK HTVYYGGFHG SHRVIIWLWD 960
ILASDFTPEE RAMFLKFVTS CSRPPLLGFA YLKPPFSIRC VEVSDDQDTG DTLGSVLRGF 1020
FTIRKREPGG RLPTSSTCFN LLKLPNYSKK SVLREKLRYA ISMNTGFELS 1070 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |