UniProt Accession

 E7EX70_HUMAN; E7EX70 

Genbank Protein ID

 AL158156 

Genbank Nucleotide ID

  

Protein Name

 DNA-directed RNA polymerase I subunit RPA49 

Protein Synonyms/Alias

  

Gene Name

 POLR1E 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	QTKTYREKMDSCIEA	ubiquitination	[1]
78	AFGTTKQKRALNTRR	ubiquitination	[1]
100	SLNRAVAKAAETIID	ubiquitination	[1, 2]
239	VPHIINTKLLKHFTC	ubiquitination	[1]
242	IINTKLLKHFTCLTY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR009668; RNA_pol-assoc_fac_A49-like. 

Pfam

 PF06870; RNA_pol_I_A49 

SMART

  

PROSITE

  

PRINTS