CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 20 
Protein Synonyms/Alias
  
Gene Name
 LRRC20 
Gene Synonyms/Alias
 UNQ2429/PRO4989 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43SFPIGIYKVLRNVSGacetylation[1]
43SFPIGIYKVLRNVSGubiquitination[2, 3, 4, 5, 6, 7]
68ELKSLTSKFMTTFSQubiquitination[4]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 REPEAT 51 72 LRR 1.
 REPEAT 75 96 LRR 2.
 REPEAT 98 120 LRR 3.
 REPEAT 121 141 LRR 4.
 REPEAT 145 167 LRR 5.  
Keyword
 Alternative splicing; Complete proteome; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 184 AA 
Protein Sequence
MLKKMGEAVA RVARKVNETV ESGSDTLDLA ECKLVSFPIG IYKVLRNVSG QIHLITLANN 60
ELKSLTSKFM TTFSQLRELH LEGNFLHRLP SEVSALQHLK AIDLSRNQFQ DFPEQLTALP 120
ALETINLEEN EIVDVPVEKL AAMPALRSIN LRFNPLNAEV RVIAPPLIKF DMLMSPEGAR 180
APLP 184 
Gene Ontology
  
Interpro
 IPR001611; Leu-rich_rpt. 
Pfam
 PF00560; LRR_1 
SMART
  
PROSITE
  
PRINTS