CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001134
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat domain-containing protein 17 
Protein Synonyms/Alias
 Gene trap ankyrin repeat protein; Serologically defined breast cancer antigen NY-BR-16 
Gene Name
 ANKRD17 
Gene Synonyms/Alias
 GTAR; KIAA0697 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
186LEAAGIGKLSTADGKubiquitination[1]
193KLSTADGKAFADPEVubiquitination[1]
636GGRTPLMKAARAGHVubiquitination[1]
695ADPTHRLKDGSTMLIubiquitination[1]
1150EAQSERTKDTPLSLAubiquitination[1]
1283ANVEHRAKTGLTPLMubiquitination[1]
1330ALTIAADKGHYKFCEubiquitination[1]
1334AADKGHYKFCELLIGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification (By similarity). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease). 
Sequence Annotation
 REPEAT 233 262 ANK 1.
 REPEAT 266 295 ANK 2.
 REPEAT 300 329 ANK 3.
 REPEAT 333 362 ANK 4.
 REPEAT 366 395 ANK 5.
 REPEAT 400 429 ANK 6.
 REPEAT 433 462 ANK 7.
 REPEAT 466 495 ANK 8.
 REPEAT 499 528 ANK 9.
 REPEAT 533 562 ANK 10.
 REPEAT 563 592 ANK 11.
 REPEAT 596 625 ANK 12.
 REPEAT 629 658 ANK 13.
 REPEAT 663 692 ANK 14.
 REPEAT 696 725 ANK 15.
 REPEAT 1082 1111 ANK 16.
 REPEAT 1115 1144 ANK 17.
 REPEAT 1149 1178 ANK 18.
 REPEAT 1182 1211 ANK 19.
 REPEAT 1217 1246 ANK 20.
 REPEAT 1251 1280 ANK 21.
 REPEAT 1284 1313 ANK 22.
 REPEAT 1319 1348 ANK 23.
 REPEAT 1352 1381 ANK 24.
 REPEAT 1385 1414 ANK 25.
 DOMAIN 1725 1789 KH.
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 803 803 Phosphoserine.
 MOD_RES 1457 1457 Phosphoserine.
 MOD_RES 1635 1635 Phosphoserine.
 MOD_RES 1696 1696 Phosphoserine.
 MOD_RES 1700 1700 Phosphoserine.
 MOD_RES 1709 1709 Phosphoserine.
 MOD_RES 2044 2044 Phosphoserine (By similarity).
 MOD_RES 2045 2045 Phosphoserine.
 MOD_RES 2047 2047 Phosphoserine.
 MOD_RES 2059 2059 Phosphoserine.
 MOD_RES 2067 2067 Phosphoserine.
 MOD_RES 2401 2401 Phosphoserine.  
Keyword
 Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2603 AA 
Protein Sequence
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS PRGMVRVCDL 60
LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG GGGGGGGGGG TSSNNSEEEE 120
DDDDEEEEVS EVESFILDQD DLENPMLETA SKLLLSGTAD GADLRTVDPE TQARLEALLE 180
AAGIGKLSTA DGKAFADPEV LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE 240
ACSEGDVNAV RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 300
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV KVLLESGASI 360
EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF KESALTLACY KGHLEMVRFL 420
LEAGADQEHK TDEMHTALME ACMDGHVEVA RLLLDSGAQV NMPADSFESP LTLAACGGHV 480
ELAALLIERG ASLEEVNDEG YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL 540
ACCGGFLEVA DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 600
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI SKGANVNRTT 660
ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM LIEAAKGGHT SVVCYLLDYP 720
NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ ALPMVVPPQE PDKPPANVAT TLPIRNKAAS 780
KQKSSSHLPA NSQDVQGYIT NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA 840
DQLTKEKIEE LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 900
QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF APIQPLAMPQ 960
ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ GILTETQQGL MVASPAQTLN 1020
DTLDDIMAAV SGRASAMSNT PTHSIAASIS QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE 1080
SNHDTALTLA CAGGHEELVQ TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA 1140
DIEAQSERTK DTPLSLACSG GRQEVVELLL ARGANKEHRN VSDYTPLSLA ASGGYVNIIK 1200
ILLNAGAEIN SRTGSKLGIS PLMLAAMNGH TAAVKLLLDM GSDINAQIET NRNTALTLAC 1260
FQGRTEVVSL LLDRKANVEH RAKTGLTPLM EAASGGYAEV GRVLLDKGAD VNAPPVPSSR 1320
DTALTIAADK GHYKFCELLI GRGAHIDVRN KKGNTPLWLA ANGGHLDVVQ LLVQAGADVD 1380
AADNRKITPL MAAFRKGHVK VVRYLVKEVN QFPSDSECMR YIATITDKEM LKKCHLCMES 1440
IVQAKDRQAA EANKNASILL EELDLEKLRE ESRRLALAAK REKRKEKRRK KKEEQRRKLE 1500
EIEAKNKENF ELQAAQEKEK LKVEDEPEVL TEPPSATTTT TIGISATWTT LAGSHGKRNN 1560
TITTTSSKRK NRKNKITPEN VQIIFDDPLP ISYSQPEKVN GESKSSSTSE SGDSDNMRIS 1620
SCSDESSNSN SSRKSDNHSP AVVTTTVSSK KQPSVLVTFP KEERKSVSGK ASIKLSETIS 1680
EGTSNSLSTC TKSGPSPLSS PNGKLTVASP KRGQKREEGW KEVVRRSKKV SVPSTVISRV 1740
IGRGGCNINA IREFTGAHID IDKQKDKTGD RIITIRGGTE STRQATQLIN ALIKDPDKEI 1800
DELIPKNRLK SSSANSKIGS SAPTTTAANT SLMGIKMTTV ALSSTSQTAT ALTVPAISSA 1860
STHKTIKNPV NNVRPGFPVS LPLAYPPPQF AHALLAAQTF QQIRPPRLPM THFGGTFPPA 1920
QSTWGPFPVR PLSPARATNS PKPHMVPRHS NQNSSGSQVN SAGSLTSSPT TTTSSSASTV 1980
PGTSTNGSPS SPSVRRQLFV TVVKTSNATT TTVTTTASNN NTAPTNATYP MPTAKEHYPV 2040
SSPSSPSPPA QPGGVSRNSP LDCGSASPNK VASSSEQEAG SPPVVETTNT RPPNSSSSSG 2100
SSSAHSNQQQ PPGSVSQEPR PPLQQSQVPP PEVRMTVPPL ATSSAPVAVP STAPVTYPMP 2160
QTPMGCPQPT PKMETPAIRP PPHGTTAPHK NSASVQNSSV AVLSVNHIKR PHSVPSSVQL 2220
PSTLSTQSAC QNSVHPANKP IAPNFSAPLP FGPFSTLFEN SPTSAHAFWG GSVVSSQSTP 2280
ESMLSGKSSY LPNSDPLHQS DTSKAPGFRP PLQRPAPSPS GIVNMDSPYG SVTPSSTHLG 2340
NFASNISGGQ MYGPGAPLGG APAAANFNRQ HFSPLSLLTP CSSASNDSSA QSVSSGVRAP 2400
SPAPSSVPLG SEKPSNVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL STSVGHSGIW 2460
SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM ERDSTGIVTP SGTFHQHVPA 2520
GYMDFPKVGG MPFSVYGNAM IPPVAPIPDG AGGPIFNGPH AADPSWNSLI KMVSSSTENN 2580
GPQTVWTGPW APHMNSVHMN QLG 2603 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0001955; P:blood vessel maturation; IEA:Compara.
 GO:0051151; P:negative regulation of smooth muscle cell differentiation; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF00013; KH_1 
SMART
 SM00248; ANK
 SM00322; KH 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50084; KH_TYPE_1 
PRINTS
 PR01415; ANKYRIN.