| Tag | Content |
|---|
| CPLM ID | CPLM-006173 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SNF1 protein kinase subunit beta-1 |
Protein Synonyms/Alias | SNF1-interacting protein 1 |
Gene Name | SIP1 |
Gene Synonyms/Alias | YDR422C; D9461.11 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 145 | GPSMATVKRTKSDLD | ubiquitination | [1] | | 499 | NASLDSEKQLNPRIR | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the PKA-regulated relocalization of the SNF1 kinase complex to the vacuolar membrane in response to various types of carbon stress. |
Sequence Annotation | REGION 473 716 Kinase-interacting sequence (KIS);
REGION 724 804 Association with SNF1 kinase complex
MOD_RES 33 33 Phosphoserine.
MOD_RES 181 181 Phosphoserine.
MOD_RES 198 198 Phosphoserine.
MOD_RES 200 200 Phosphoserine.
MOD_RES 206 206 Phosphoserine.
MOD_RES 209 209 Phosphoserine.
MOD_RES 220 220 Phosphoserine.
MOD_RES 331 331 Phosphoserine.
MOD_RES 494 494 Phosphoserine.
MOD_RES 497 497 Phosphoserine.
MOD_RES 643 643 Phosphoserine.
LIPID 2 2 N-myristoyl glycine (Potential). |
Keyword | Complete proteome; Cytoplasm; Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome; Vacuole. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 815 AA |
Protein Sequence | MGNSPSTQDP SHSTKKEHGH HFHDAFNKDR QGSITSQLFN NRKSTHKRRA SHTSEHNGAI 60
PPRMQLLASH DPSTDCDGRM SSDTTIDKGP SHLFKKDYSL SSAADVNDTT LANLTLSDDH 120
DVGAPEEQVK SPSFLSPGPS MATVKRTKSD LDDLSTLNYT MVDETTENER NDKPHHERHR 180
SSIIALKKNL LESSATASPS PTRSSSVHSA SLPALTKTDS IDIPVRQPYS KKPSIHAYQY 240
QYLNNDETFS ENSQMDKEGN SDSVDAEAGV LQSEDMVLNQ SLLQNALKKD MQRLSRVNSS 300
NSMYTAERIS HANNNGNIEN NTRNKGNAGG SNDDFTAPIS ATAKMMMKLY GDKTLMERDL 360
NKHHNKTKKA QNKKIRSVSN SRRSSFASLH SLQSRKSILT NGLNLQPLHP LHPIINDNES 420
QYSAPQHREI SHHSNSMSSM SSISSTNSTE NTLVVLKWKD DGTVAATTEV FIVSTDIASA 480
LKEQRELTLD ENASLDSEKQ LNPRIRMVYD DVHKEWFVPD LFLPAGIYRL QFSINGILTH 540
SNFLPTATDS EGNFVNWFEV LPGYHTIEPF RNEADIDSQV EPTLDEELPK RPELKRFPSS 600
SRKSSYYSAK GVERPSTPFS DYRGLSRSSS INMRDSFVRL KASSLDLMAE VKPERLVYSN 660
EIPNLFNIGD GSTISVKGDS DDVHPQEPPS FTHRVVDCNQ DDLFATLQQG GNIDAETAEA 720
VFLSRYPVPD LPIYLNSSYL NRILNQSNQN SESHERDEGA INHIIPHVNL NHLLTSSIRD 780
EIISVACTTR YEGKFITQVV YAPCYYKTQK SQISN 815 |
Gene Ontology | GO:0031588; C:AMP-activated protein kinase complex; IDA:SGD. GO:0000324; C:fungal-type vacuole; IDA:SGD. GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell. GO:0006468; P:protein phosphorylation; IGI:SGD. GO:0043254; P:regulation of protein complex assembly; IGI:SGD. GO:0007165; P:signal transduction; IGI:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |