UniProt Accession

 ANXA7_HUMAN; P20073; Q5F2H3; Q5T0M6; Q5T0M7 

Genbank Protein ID

 J04543; AB062429; BT007187; CR407686; AL512656; AL353731; AL512656; AL353731; AL353731; AL353731; AL512656; AL353731; AL512656; CH471083; CH471083; BC002632 

Genbank Nucleotide ID

 AAA36616.1; BAB93492.1; AAP35851.1; CAG28614.1; CAI15290.1; CAI15290.1; CAI15291.1; CAI15291.1; CAI52483.1; CAI52484.1; CAI52484.1; CAI52485.1; CAI52485.1; EAW54493.1; EAW54494.1; AAH02632.1 

Protein Name

 Annexin A7 

Protein Synonyms/Alias

 Annexin VII; Annexin-7; Synexin 

Gene Name

 ANXA7 

Gene Synonyms/Alias

 ANX7; SNX; OK/SW-cl.95 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
199	EILRKAMKGFGTDEQ	ubiquitination	[1, 2]
224	NDQRQKIKAAFKTSY	ubiquitination	[2]
228	QKIKAAFKTSYGKDL	ubiquitination	[2]
233	AFKTSYGKDLIKDLK	acetylation	[3]
233	AFKTSYGKDLIKDLK	ubiquitination	[2]
237	SYGKDLIKDLKSELS	ubiquitination	[1, 2]
309	EFGRDLEKDIRSDTS	ubiquitination	[2]
430	ERLYYAMKGAGTDDS	ubiquitination	[1, 2, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. 

Sequence Annotation

 REPEAT 5 9 1.
 REPEAT 10 14 2.
 REPEAT 16 20 3.
 REPEAT 189 254 Annexin 1.
 REPEAT 266 326 Annexin 2.
 REPEAT 349 409 Annexin 3.
 REPEAT 425 485 Annexin 4.
 REGION 1 143 Repeat-rich region.
 REGION 5 20 3 X 5 AA tandem repeats of G-Y-P-P-X.
 MOD_RES 233 233 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 488 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:BHF-UCL.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0009992; P:cellular water homeostasis; IEA:Compara.
 GO:0007599; P:hemostasis; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0035176; P:social behavior; IEP:UniProtKB. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR013286; AnnexinVII. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR01871; ANNEXINVII.