UniProt Accession

 TCTP_YEAST; P35691; D6VXN1 

Genbank Protein ID

 X75781; Z28056; BK006944 

Genbank Nucleotide ID

 CAA53416.1; CAA81893.1; DAA09101.1 

Protein Name

 Translationally-controlled tumor protein homolog 

Protein Synonyms/Alias

 TCTP; Microtubule and mitochondria-interacting protein 1; Translation machinery-associated protein 19 

Gene Name

 TMA19 

Gene Synonyms/Alias

 MMI1; YKL056C; YKL312 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
5	***MIIYKDIFSNDE	ubiquitination	[1]
80	LQQTAFDKKSFLTYI	acetylation	[2]
80	LQQTAFDKKSFLTYI	ubiquitination	[1]
81	QQTAFDKKSFLTYIK	acetylation	[2]
88	KSFLTYIKGYMKAVK	acetylation	[2]
92	TYIKGYMKAVKAKLQ	ubiquitination	[1]
97	YMKAVKAKLQETNPE	acetylation	[2]
97	YMKAVKAKLQETNPE	ubiquitination	[1]
108	TNPEEVPKFEKGAQT	acetylation	[2]
108	TNPEEVPKFEKGAQT	ubiquitination	[1]
111	EEVPKFEKGAQTYVK	acetylation	[2]
118	KGAQTYVKKVIGSFK	acetylation	[2]
166	KHGIVEEKI******	acetylation	[2]
166	KHGIVEEKI******	ubiquitination	[1, 3]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Involved in protein synthesis. Involved in microtubule stabilization. 

Sequence Annotation

 MOD_RES 9 9 Phosphoserine.
 MOD_RES 15 15 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule; Mitochondrion; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
 GO:0002181; P:cytoplasmic translation; IMP:SGD. 

Interpro

 IPR011057; Mss4-like.
 IPR011323; Mss4/transl-control_tumor.
 IPR018103; Translation_control_tumour_CS.
 IPR018105; Translational_control_tumour_p. 

Pfam

 PF00838; TCTP 

SMART

  

PROSITE

 PS01002; TCTP_1
 PS01003; TCTP_2 

PRINTS

 PR01653; TCTPROTEIN.