UniProt Accession

 KIN17_HUMAN; O60870 

Genbank Protein ID

 AJ005273; AL158044; BC017309 

Genbank Nucleotide ID

 CAA06462.1; CAI12959.1; AAH17309.1 

Protein Name

 DNA/RNA-binding protein KIN17 

Protein Synonyms/Alias

 Binding to curved DNA; KIN, antigenic determinant of recA protein homolog 

Gene Name

 KIN 

Gene Synonyms/Alias

 BTCD; KIN17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
292	IIVKIITKKLGEKYH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. 

Sequence Annotation

 ZN_FING 28 50 C2H2-type.
 REGION 284 334 C-terminal subdomain A.
 REGION 340 391 C-terminal subdomain B.
 MOD_RES 135 135 N6,N6,N6-trimethyllysine; by METTL22; in  

Keyword

 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; DNA replication; DNA-binding; Host-virus interaction; Metal-binding; Methylation; mRNA processing; Nucleus; Reference proteome; RNA-binding; Stress response; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016363; C:nuclear matrix; IDA:UniProtKB.
 GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IDA:UniProtKB.
 GO:0006397; P:mRNA processing; TAS:UniProtKB.
 GO:0006974; P:response to DNA damage stimulus; IEP:UniProtKB.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR019447; DNA/RNA-bd_Kin17_cons_domain.
 IPR015880; Znf_C2H2-like. 

Pfam

 PF10357; Kin17_mid 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS