UniProt Accession

 A8YXX4_HUMAN; A8YXX4 

Genbank Protein ID

 AY947343; AK122784; CH471067 

Genbank Nucleotide ID

 AAY57874.1; BAG53728.1; EAW91116.1 

Protein Name

 Glutamine synthetase 

Protein Synonyms/Alias

  

Gene Name

 PIG59 

Gene Synonyms/Alias

 GLUL; hCG_24393 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	SASSHLNKGIKQVYM	ubiquitination	[1]
14	SHLNKGIKQVYMSLP	ubiquitination	[1]
91	MFRDPFRKDPNKLVL	ubiquitination	[1]
95	PFRKDPNKLVLCEVF	ubiquitination	[1, 2]
103	LVLCEVFKYNRRPAE	ubiquitination	[1]
259	CHTNFSTKAMREENG	ubiquitination	[1]
268	MREENGLKYIEEAIE	ubiquitination	[1]
276	YIEEAIEKLSKRHQY	ubiquitination	[1]
372	GDEPFQYKN******	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

  

Keyword

 Ligase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043204; C:perikaryon; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0016595; F:glutamate binding; IEA:Compara.
 GO:0004356; F:glutamate-ammonia ligase activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0006536; P:glutamate metabolic process; IEA:Compara.
 GO:0006542; P:glutamine biosynthetic process; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara. 

Interpro

 IPR008147; Gln_synt_beta.
 IPR014746; Gln_synth/guanido_kin_cat_dom.
 IPR008146; Gln_synth_cat_dom.
 IPR027303; Gln_synth_gly_rich_site.
 IPR027302; Gln_synth_N_conserv_site. 

Pfam

 PF00120; Gln-synt_C
 PF03951; Gln-synt_N 

SMART

  

PROSITE

 PS00180; GLNA_1
 PS00181; GLNA_ATP 

PRINTS