CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cohesin subunit SCC3 
Protein Synonyms/Alias
 Irregular cell behavior protein 1 
Gene Name
 IRR1 
Gene Synonyms/Alias
 SCC3; YIL026C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
36AQHVESDKITAKTQHacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the MCD1/SCC1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. 
Sequence Annotation
 DOMAIN 367 457 SCD.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 628 628 Phosphoserine.  
Keyword
 Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Coiled coil; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1150 AA 
Protein Sequence
MTAVRRSTRI RTKSQVIEED YDDEQNTSAQ HVESDKITAK TQHEEEEEQD TGESEESSSE 60
DDYEDQDDDD YVDTATAKRK SRKRKPKSAS NTSSKRQKKK PTSAQKSAVS HAPAYHRSKK 120
DQDQYLEIAK DFQPTELFDI LSTSEDVSIE ELLREWLETY SENRDKFLQE FINLLLNCCG 180
SVARVEDHDV HSNESSNETI GEIQLLFQRQ KLHEFYLLIS KENKKRKNFK MGPLYQNFAE 240
FMTKLLEVAN DLQLLYVESD EDDTQIVTGN LVLDLLTWLS SFSVCKIRCF RYISTLTLYL 300
FQDYLTQQAV NLEKNYLAKL SKQLSLEEKK KRPNNKTLEK LESTIAETQG SKVVIDSIID 360
NIVKLCFVHR YKDVSDLIRS ESMLHLSIWI KNYPEYFLKV TFLKYFGWLL SDNSVSVRLQ 420
VTKILPHLII QNHNSKSTDN SAIRQVFERF KTKILEVAIR DVNLDVRIHS IQVLTEASSL 480
GYLDDSEILI ISSLMFDEEF DPFKTSSFNK RSKFLSTVAK FLARVIKEKF DEFIKTHEDL 540
PKEVDGLEVG PVVQVGIFIK ILNDSLIYHL KDCAEVDSRT KIRMLTQAAE FLSPYISTHL 600
KTICNLLISD TESNELIQKL QNSANNNSDD EDVDDEELDI TPLFPIDRNS TILYLNVFHG 660
LCAGANNPKI QTKDSVKEIV LPLFYDLLNA ASIESADILC PLLESFITFS LDDWISIGYE 720
TELKKITDKT IKAFMDSTIG NSKVDMKYDI FAKFIHHIHH FEKKELQEKF LNQIATLKIH 780
LKKFLQEKMD PNNSRDDYKD LTCSLYELYI NKLTILGRDY PIEVDEELLQ LFLNNFVSRI 840
PIMFQDFDDS TAQEINFKML VLLATWNLEK WREIIEKVRD YENSISKDLR SVWKPIAAII 900
GRLNTLVISL AATNETFENI NSLFYLKWSA CTSLMDIIVA IKIFELKLPA DATTWRYSMS 960
EQFPFYLHDN ASKVLLKIFL YLESLFAKQV DVQLERVADE DANLNDLPET GFFENIETEF 1020
LLFTVKLKGL MKLNILDERF ASRVALNKEK LGPLFKKIVD DTIMENPEPN KKNIQKAKSN 1080
QTQREKAPLQ PNSERETDHA NTENNDPDIP MTIDLEPIEE SSQNNSELAP IEEHPTVVDA 1140
IDNSDEITQD 1150 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0034990; C:nuclear mitotic cohesin complex; IDA:SGD.
 GO:0003682; F:chromatin binding; IDA:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000755; P:cytogamy; IMP:SGD.
 GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
 GO:0007064; P:mitotic sister chromatid cohesion; IMP:SGD.
 GO:0006473; P:protein acetylation; IDA:UniProtKB.
 GO:0009847; P:spore germination; IMP:SGD. 
Interpro
 IPR016024; ARM-type_fold.
 IPR020839; SCD.
 IPR013721; STAG. 
Pfam
 PF08514; STAG 
SMART
  
PROSITE
 PS51425; SCD 
PRINTS