CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor expression-enhancing protein 4 
Protein Synonyms/Alias
  
Gene Name
 REEP4 
Gene Synonyms/Alias
 C8orf20; PP432 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90GASLLYRKFVHPSLSubiquitination[1, 2, 3]
101PSLSRHEKEIDAYIVubiquitination[2, 4]
111DAYIVQAKERSYETVubiquitination[1, 2, 3, 4, 5]
123ETVLSFGKRGLNIAAubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 May enhance the cell surface expression of odorant receptors (By similarity). 
Sequence Annotation
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 196 196 Phosphothreonine.
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 250 250 Phosphothreonine.
 MOD_RES 253 253 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 257 AA 
Protein Sequence
MVSWMICRLV VLVFGMLCPA YASYKAVKTK NIREYVRWMM YWIVFALFMA AEIVTDIFIS 60
WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDAYIVQA KERSYETVLS 120
FGKRGLNIAA SAAVQAATKS QGALAGRLRS FSMQDLRSIS DAPAPAYHDP LYLEDQVSHR 180
RPPIGYRAGG LQDSDTEDEC WSDTEAVPRA PARPREKPLI RSQSLRVVKR KPPVREGTSR 240
SLKVRTRKKT VPSDVDS 257 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR004345; TB2_DP1_HVA22. 
Pfam
 PF03134; TB2_DP1_HVA22 
SMART
  
PROSITE
  
PRINTS