CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022892
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein NipSnap homolog 3A 
Protein Synonyms/Alias
 NipSnap3A; Protein NipSnap homolog 4; NipSnap4; Target for Salmonella secreted protein C; TassC 
Gene Name
 NIPSNAP3A 
Gene Synonyms/Alias
 NIPSNAP4; HSPC299 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45EFRSYYLKPSKMNEFacetylation[1, 2, 3]
48SYYLKPSKMNEFLENacetylation[1]
166ALWGDAFKRAVHAHVacetylation[1, 2, 3, 4]
166ALWGDAFKRAVHAHVubiquitination[5, 6]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 48 48 N6-acetyllysine.
 MOD_RES 166 166 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 247 AA 
Protein Sequence
MLVLRSALTR ALASRTLAPQ MCSSFATGPR QYDGIFYEFR SYYLKPSKMN EFLENFEKNA 60
HLRTAHSELV GYWSVEFGGR MNTVFHIWKY DNFAHRTEVR KALAKDKEWQ EQFLIPNLAL 120
IDKQESEITY LVPWCKLEKP PKEGVYELAT FQMKPGGPAL WGDAFKRAVH AHVNLGYTKL 180
VGVFHTEYGA LNRVHVLWWN ESADSRAAGR HKSHEDPRVV AAVRESVNYL VSQQNMLLIP 240
TSFSPLK 247 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara. 
Interpro
 IPR011008; Dimeric_a/b-barrel.
 IPR012577; NIPSNAP. 
Pfam
 PF07978; NIPSNAP 
SMART
  
PROSITE
  
PRINTS