| Tag | Content |
|---|
| CPLM ID | CPLM-011044 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Growth factor receptor-bound protein 7 |
Protein Synonyms/Alias | Epidermal growth factor receptor GRB-7; GRB7 adapter protein |
Gene Name | Grb7 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 347 | KYGVQLYKNYQQAQS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. |
Sequence Annotation | DOMAIN 99 185 Ras-associating.
DOMAIN 228 341 PH.
DOMAIN 434 530 SH2.
MOD_RES 187 187 Phosphotyrosine; by FAK1 (By similarity).
MOD_RES 300 300 Phosphothreonine.
MOD_RES 341 341 Phosphotyrosine; by FAK1 (By similarity).
MOD_RES 364 364 Phosphoserine (By similarity).
MOD_RES 369 369 Phosphoserine. |
Keyword | Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Lipid-binding; Membrane; Phosphoprotein; Reference proteome; Repressor; RNA-binding; SH2 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 535 AA |
Protein Sequence | MELDLSPTHL SSSPEDVCPT PATPPETPPP PDNPPPGDVK RSQPLPIPSS RKLREEEFQA 60
TSLPSIPNPF PELCSPPSQK PILGGSSGAR GLLPRDSSRL CVVKVYSEDG ACRSVEVAAG 120
ATARHVCEML VQRAHALSDE SWGLVESHPY LALERGLEDH EFVVEVQEAW PVGGDSRFIF 180
RKNFAKYELF KSPPHTLFPE KMVSSCLDAQ TGISHEDLIQ NFLNAGSFPE IQGFLQLRGS 240
GRGSGRKLWK RFFCFLRRSG LYYSTKGTSK DPRHLQYVAD VNESNVYVVT QGRKLYGMPT 300
DFGFCVKPNK LRNGHKGLHI FCSEDEQSRT CWLAAFRLFK YGVQLYKNYQ QAQSRHLRLS 360
YLGSPPLRSV SDNTLVAMDF SGHAGRVIDN PREALSAAME EAQAWRKKTN HRLSLPTTCS 420
GSSLSAAIHR TQPWFHGRIS REESQRLIGQ QGLVDGVFLV RESQRNPQGF VLSLCHLQKV 480
KHYLILPSED EGCLYFSMDE GQTRFTDLLQ LVEFHQLNRG ILPCLLRHCC ARVAL 535 |
Gene Ontology | GO:0042995; C:cell projection; IEA:UniProtKB-SubCell. GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB. GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005925; C:focal adhesion; ISS:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0005070; F:SH3/SH2 adaptor activity; TAS:MGI. GO:0017148; P:negative regulation of translation; IMP:UniProtKB. GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB. GO:0007165; P:signal transduction; TAS:MGI. GO:0034063; P:stress granule assembly; IMP:UniProtKB. |
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