CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014438
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucuronosyltransferase 1-9 
Protein Synonyms/Alias
 UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UDP-glucuronosyltransferase 1-7; UDPGT; UDP-glucuronosyltransferase 1A9; UGT1A12; UGTP4 
Gene Name
 Ugt1a9 
Gene Synonyms/Alias
 Ugt1; Ugt1a12 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
97YLSYTQWKTPEHSIRacetylation[1]
97YLSYTQWKTPEHSIRsuccinylation[1]
194YVPRLFSKYTDTMTFubiquitination[2]
348AKNTILVKWLPQNDLacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647
Functional Description
 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 
Sequence Annotation
 MOD_RES 348 348 N6-acetyllysine.
 CARBOHYD 69 69 N-linked (GlcNAc...) (Potential).
 CARBOHYD 290 290 N-linked (GlcNAc...) (Potential).
 CARBOHYD 428 428 N-linked (GlcNAc...) (Potential).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Microsome; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 528 AA 
Protein Sequence
MAPVAFPTSF FLCLLLASGL AQAGRLLVVP MDGSHWFTMQ MVVEKLIHRG HEVVVVIPEV 60
SWQLGKSLNC TVKTYSISHT LEDLDREFKY LSYTQWKTPE HSIRSFLTGS ARGFFELTFS 120
HCRSLFNDKK LVEYLKQRFF DAVFLDPFDV CGLIVAKYFS LPSVIFARGV FCDYLEEGAQ 180
CPSLPSYVPR LFSKYTDTMT FKERVWNHLI YIEEHAFCSY FLRTAVEVAS EILQTPVTMT 240
DLFSPVSIWL LRTDFVLEFP RPVMPNMVFI GGINCLQKKS LSKEFEAYVN ASGEHGIVVF 300
SLGSMVSEIP EKKAMEIAEA LGRIPQTVLW RYTGTRPSNL AKNTILVKWL PQNDLLGHPK 360
TRAFITHSGS HGIYEGICNG VPMVMMPLFG DQMDNAKRME TRGAGVTLNV LEMTADDLEN 420
ALKTVINNKS YKENIMRLSS LHKDRPIEPL DLAVFWVEYV MRHKGAPHLR PAAHDLTWYQ 480
YHSLDVIGFL LAIVLTVVFI VFKCCAYGCR KCFGGKGRVK KSHKSKTH 528 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015020; F:glucuronosyltransferase activity; IEA:EC. 
Interpro
 IPR002213; UDP_glucos_trans. 
Pfam
 PF00201; UDPGT 
SMART
  
PROSITE
 PS00375; UDPGT 
PRINTS