CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000719
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prominin-1 
Protein Synonyms/Alias
 Antigen AC133; Prominin-like protein 1; CD133 
Gene Name
 PROM1 
Gene Synonyms/Alias
 PROML1; MSTP061 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82TLRKFLQKAYESKIDacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. 
Sequence Annotation
 MOD_RES 863 863 Phosphoserine.
 CARBOHYD 220 220 N-linked (GlcNAc...) (Potential).
 CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
 CARBOHYD 395 395 N-linked (GlcNAc...) (Potential).
 CARBOHYD 414 414 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 580 580 N-linked (GlcNAc...) (Potential).
 CARBOHYD 729 729 N-linked (GlcNAc...) (Potential).
 CARBOHYD 730 730 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell membrane; Cell projection; Cilium; Complete proteome; Cone-rod dystrophy; Direct protein sequencing; Disease mutation; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Retinitis pigmentosa; Signal; Stargardt disease; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 865 AA 
Protein Sequence
MALVLGSLLL LGLCGNSFSG GQPSSTDAPK AWNYELPATN YETQDSHKAG PIGILFELVH 60
IFLYVVQPRD FPEDTLRKFL QKAYESKIDY DKPETVILGL KIVYYEAGII LCCVLGLLFI 120
ILMPLVGYFF CMCRCCNKCG GEMHQRQKEN GPFLRKCFAI SLLVICIIIS IGIFYGFVAN 180
HQVRTRIKRS RKLADSNFKD LRTLLNETPE QIKYILAQYN TTKDKAFTDL NSINSVLGGG 240
ILDRLRPNII PVLDEIKSMA TAIKETKEAL ENMNSTLKSL HQQSTQLSSS LTSVKTSLRS 300
SLNDPLCLVH PSSETCNSIR LSLSQLNSNP ELRQLPPVDA ELDNVNNVLR TDLDGLVQQG 360
YQSLNDIPDR VQRQTTTVVA GIKRVLNSIG SDIDNVTQRL PIQDILSAFS VYVNNTESYI 420
HRNLPTLEEY DSYWWLGGLV ICSLLTLIVI FYYLGLLCGV CGYDRHATPT TRGCVSNTGG 480
VFLMVGVGLS FLFCWILMII VVLTFVFGAN VEKLICEPYT SKELFRVLDT PYLLNEDWEY 540
YLSGKLFNKS KMKLTFEQVY SDCKKNRGTY GTLHLQNSFN ISEHLNINEH TGSISSELES 600
LKVNLNIFLL GAAGRKNLQD FAACGIDRMN YDSYLAQTGK SPAGVNLLSF AYDLEAKANS 660
LPPGNLRNSL KRDAQTIKTI HQQRVLPIEQ SLSTLYQSVK ILQRTGNGLL ERVTRILASL 720
DFAQNFITNN TSSVIIEETK KYGRTIIGYF EHYLQWIEFS ISEKVASCKP VATALDTAVD 780
VFLCSYIIDP LNLFWFGIGK ATVFLLPALI FAVKLAKYYR RMDSEDVYDD VETIPMKNME 840
NGNNGYHKDH VYGIHNPVMT SPSQH 865 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005903; C:brush border; IEA:Compara.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
 GO:0042622; C:photoreceptor outer segment membrane; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0032420; C:stereocilium; IEA:Compara.
 GO:0042805; F:actinin binding; IDA:BHF-UCL.
 GO:0060219; P:camera-type eye photoreceptor cell differentiation; ISS:UniProtKB.
 GO:0072139; P:glomerular parietal epithelial cell differentiation; IMP:UniProtKB.
 GO:0072112; P:glomerular visceral epithelial cell differentiation; IMP:UniProtKB.
 GO:0045494; P:photoreceptor cell maintenance; IMP:BHF-UCL.
 GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; IMP:UniProtKB.
 GO:0010842; P:retina layer formation; ISS:UniProtKB. 
Interpro
 IPR008795; Prominin. 
Pfam
 PF05478; Prominin 
SMART
  
PROSITE
  
PRINTS