UniProt Accession

 BORG4_MOUSE; Q9JM96; Q3TNF3; Q9QZT8 

Genbank Protein ID

 AB035088; AK075739; AK165318; BC003857; AF165114 

Genbank Nucleotide ID

 BAA95932.1; BAC35920.1; BAE38136.1; AAH03857.1; AAD47822.1 

Protein Name

 Cdc42 effector protein 4 

Protein Synonyms/Alias

 Binder of Rho GTPases 4 

Gene Name

 Cdc42ep4 

Gene Synonyms/Alias

 Borg4; Cep4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	VSSSVNSKRRSRADL	ubiquitination	[1]
56	DTSFLTSKAREADDE	ubiquitination	[1]
112	RDSALFVKNAMSLPQ	ubiquitination	[1]
123	SLPQLNEKEAAEKDS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. 

Sequence Annotation

 DOMAIN 27 41 CRIB.
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 116 116 Phosphoserine (By similarity).
 MOD_RES 136 136 Phosphoserine (By similarity).
 MOD_RES 138 138 Phosphoserine (By similarity).
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 140 140 Phosphoserine (By similarity).
 MOD_RES 154 154 Phosphoserine.
 MOD_RES 165 165 Phosphoserine (By similarity).
 MOD_RES 223 223 Phosphoserine.
 MOD_RES 285 285 Phosphoserine (By similarity).
 MOD_RES 288 288 Phosphoserine (By similarity).  

Keyword

 Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0007266; P:Rho protein signal transduction; IDA:MGI. 

Interpro

 IPR000095; PAK_box_Rho-bd. 

Pfam

 PF00786; PBD 

SMART

  

PROSITE

 PS50108; CRIB 

PRINTS