| Tag | Content |
|---|
| CPLM ID | CPLM-020957 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lon protease homolog 2, peroxisomal |
Protein Synonyms/Alias | Lon protease-like protein 2; Lon protease 2; Peroxisomal Lon protease |
Gene Name | Lonp2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 348 | NDHYAMEKLKRRVLE | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1 (By similarity). |
Sequence Annotation | DOMAIN 13 219 Lon.
NP_BIND 375 382 ATP (Potential).
MOTIF 850 852 Microbody targeting signal (Potential).
ACT_SITE 743 743 By similarity.
ACT_SITE 786 786 By similarity. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding; Peroxisome; Protease; Reference proteome; Serine protease. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 852 AA |
Protein Sequence | MSSVSPIQIP SRLPLLLTHE SVLLPGSTMR TSVDTARNLQ LVRSRLLKGT SLQSTILGVI 60
PNTPDPASDT QDLPPLHRIG TAALAVQVVG SNWPKPHYTL LITGLCRFQI VQVLKEKPYP 120
VAEVEQLDRL EEFPNICKSR EELGELSEQF YRYAVQLVEM LDMSVPAVAK LRRLLDNLPR 180
EALPDILTSI IRTSNKEKLQ ILDAVSLEDR FKMTIPLLVR QIEGLKLLQK TRKPKQDDDK 240
RVIAIRPIRR IPHIPGTLED EEEEEDNDDI VMLEKKIRTS SMPEQAHKVC VKEIKRLKKM 300
PQSMPEYALT RNYLELMVEL PWNKSTTDRL DIRAARILLD NDHYAMEKLK RRVLEYLAVR 360
QLKNNLKGPI LCFVGPPGVG KTSVGRSVAK TLGREFHRIA LGGVCDQSDI RGHRRTYVGS 420
MPGRIINGLK TVGVNNPVFL LDEVDKLGKS LQGDPAAALL EVLDPEQNHN FTDHYLNVAF 480
DLSQVLFIAT ANTTATIPPA LLDRMEIIQV PGYTQEEKIE IAHRHLIPKQ LEQHGLTPQQ 540
IQIPQHTTLA IITRYTREAG VRSLDRKFGA ICRAVAVKVA EGQHKEAKLD RSDVADGEGC 600
KEHVLEDAKP ESISDTADLA LPPEMPILID SHALKDILGP PLYELEVMIL ISMFTLVLA 659 |
Gene Ontology | GO:0009295; C:nucleoid; IBA:RefGenome. GO:0005634; C:nucleus; IDA:MGI. GO:0005782; C:peroxisomal matrix; ISS:HGNC. GO:0005524; F:ATP binding; IBA:RefGenome. GO:0004176; F:ATP-dependent peptidase activity; IBA:RefGenome. GO:0043565; F:sequence-specific DNA binding; IBA:RefGenome. GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome. GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IBA:RefGenome. GO:0016558; P:protein import into peroxisome matrix; IEA:HAMAP. GO:0016485; P:protein processing; IBA:RefGenome. GO:0031998; P:regulation of fatty acid beta-oxidation; IEA:Compara. GO:0014070; P:response to organic cyclic compound; IEA:Compara. GO:0006465; P:signal peptide processing; IEA:Compara. |
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