UniProt Accession

 MDHP_YEAST; P32419; D6VRS1; Q12689 

Genbank Protein ID

 M98763; Z74126; BK006938 

Genbank Nucleotide ID

 AAA34767.1; CAA98644.1; DAA11781.1 

Protein Name

 Malate dehydrogenase, peroxisomal 

Protein Synonyms/Alias

  

Gene Name

 MDH3 

Gene Synonyms/Alias

 YDL078C; D2468 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
106	SLVTAVGKFAPNARI	acetylation	[1]
106	SLVTAVGKFAPNARI	ubiquitination	[2]
138	LKKMGKFKPGNVMGV	ubiquitination	[2]
167	YLMLKNPKIGQEQDK	ubiquitination	[2]
174	KIGQEQDKTTMHRKV	ubiquitination	[2]
225	FGGDEIVKAKQGAGS	ubiquitination	[2]
256	LRSFHNEKPETESLS	ubiquitination	[2]
324	QLVNTAVKELRKNIE	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 NP_BIND 8 14 NAD (By similarity).
 NP_BIND 116 118 NAD (By similarity).
 ACT_SITE 187 187 Proton acceptor (By similarity).
 BINDING 34 34 NAD (By similarity).
 BINDING 80 80 Substrate (By similarity).
 BINDING 86 86 Substrate (By similarity).
 BINDING 93 93 NAD (By similarity).
 BINDING 118 118 Substrate (By similarity).
 BINDING 152 152 Substrate (By similarity).
 BINDING 237 237 NAD (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Glyoxylate bypass; NAD; Oxidoreductase; Peroxisome; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 343 AA 

Protein Sequence

Gene Ontology

 GO:0005782; C:peroxisomal matrix; IDA:SGD.
 GO:0030060; F:L-malate dehydrogenase activity; IMP:SGD.
 GO:0003729; F:mRNA binding; IDA:SGD.
 GO:0006635; P:fatty acid beta-oxidation; TAS:SGD.
 GO:0006097; P:glyoxylate cycle; TAS:SGD.
 GO:0006108; P:malate metabolic process; TAS:SGD.
 GO:0006735; P:NADH regeneration; TAS:SGD.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR001252; Malate_DH_AS.
 IPR010097; Malate_DH_type1.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00068; MDH 

PRINTS