CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 THO complex subunit 2 
Protein Synonyms/Alias
  
Gene Name
 THOC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10RCTALQDKLLEEEKKubiquitination[1]
33LQRLKLEKDNWLLAKubiquitination[1]
40KDNWLLAKSTKNETIubiquitination[1, 2]
80VELVHQQKTPNFSTLubiquitination[1]
135SDRATYEKECGNYPGubiquitination[1, 2, 3]
157TGFDGGNKADQLDYEubiquitination[1, 2, 3, 4, 5]
209KILPWYPKVLNLGQAubiquitination[1]
269GCYSGQLKSRKSYMIubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 380 AA 
Protein Sequence
XERCTALQDK LLEEEKKQME HVQRVLQRLK LEKDNWLLAK STKNETITKF LQLCIFPRCI 60
FSAIDAVYCA RFVELVHQQK TPNFSTLLCY DRVFSDIIYT VASCTENEAS RYGRFLCCML 120
ETVTRWHSDR ATYEKECGNY PGFLTILRAT GFDGGNKADQ LDYENFRHVV HKWHYKLTKA 180
SVHCLETGEY THIRNILIVL TKILPWYPKV LNLGQALERR VHKICQEEKE KRPDLYALAM 240
GVEVYLLPSG DYGRLCDHVS TGCYSGQLKS RKSYMIPENE FHHKDPPPRN AVASVQNGPG 300
GGPSSSSIGS ASKSDESSTE ETDKSRERSQ CGVKAVNKAS STTPKGNSSN GNSGSNSNKA 360
VKENDKEKGK EKEKEKKEKT 380 
Gene Ontology
  
Interpro
 IPR021418; THO_THOC2_C. 
Pfam
 PF11262; Tho2 
SMART
  
PROSITE
  
PRINTS