UniProt Accession

 SC11B_HUMAN; P0C7V7 

Genbank Protein ID

 AC091076 

Genbank Nucleotide ID

  

Protein Name

 Putative signal peptidase complex catalytic subunit SEC11B 

Protein Synonyms/Alias

 SEC11 homolog B; SEC11-like protein 2 

Gene Name

 SEC11B 

Gene Synonyms/Alias

 SEC11L2; SPCS4B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	PIVHRVLKIHEKQNG	ubiquitination	[1]
91	RVLKIHEKQNGHIKF	ubiquitination	[2, 3]
101	GHIKFLTKGDNNAVD	ubiquitination	[2, 3, 4]
114	VDDRGLYKQDQHWLE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Putative component of some signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). 

Sequence Annotation

 ACT_SITE 43 43 By similarity.  

Keyword

 Complete proteome; Hydrolase; Membrane; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 166 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 

Interpro

 IPR019758; Pept_S26A_signal_pept_1_CS.
 IPR019759; Peptidase_S24_S26.
 IPR001733; Peptidase_S26B. 

Pfam

 PF00717; Peptidase_S24 

SMART

  

PROSITE

 PS00501; SPASE_I_1
 PS00761; SPASE_I_3 

PRINTS

 PR00728; SIGNALPTASE.