UniProt Accession

 T2EB_HUMAN; P29084; D3DSV2; Q9H2B9 

Genbank Protein ID

 S67861; X63469; AF292062; AF292056; AF292057; AF292058; AF292059; AF292060; AF292061; CH471080; CH471080; BC030572 

Genbank Nucleotide ID

 AAB20414.1; CAA45069.1; AAG39077.1; AAG39077.1; AAG39077.1; AAG39077.1; AAG39077.1; AAG39077.1; AAG39077.1; EAW63446.1; EAW63449.1; AAH30572.1 

Protein Name

 Transcription initiation factor IIE subunit beta 

Protein Synonyms/Alias

 TFIIE-beta; General transcription factor IIE subunit 2 

Gene Name

 GTF2E2 

Gene Synonyms/Alias

 TF2E2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	HGGSSGSKQNSDHSN	acetylation	[1]
116	LDIGLKQKQWLMTEA	ubiquitination	[2]

Reference

 [1] Acetylation of general transcription factors by histone acetyltransferases.
 Imhof A, Yang XJ, Ogryzko VV, Nakatani Y, Wolffe AP, Ge H.
 Curr Biol. 1997 Sep 1;7(9):689-92. [PMID: 9285713]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. 

Sequence Annotation

 DNA_BIND 66 146 TFIIE beta.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 291 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005673; C:transcription factor TFIIE complex; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR016656; TFIIE-bsu.
 IPR003166; TFIIE_bsu_DNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF02186; TFIIE_beta 

SMART

  

PROSITE

 PS51351; TFIIE_BETA_C 

PRINTS