CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD and tetratricopeptide repeats protein 1 
Protein Synonyms/Alias
  
Gene Name
 Wdtc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
423DALRDCLKAISLNPCubiquitination[1]
485ITAALFSKSDGEEKKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 615 AA 
Protein Sequence
MAKVNITRDL IRRQVKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 60
LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 120
LTVKETIHMF GDHTNRVKRI ATAPMWPNTF WSAAEDGLIR QYDLRENSKH SEVLIDLTEY 180
CGPMVEAKCL TVNPQDNNCL AVGASGPFVR LYDIRMIHNH RKSMRQSPSA GVHTFCDRQK 240
PLPDGAAQYY VAGHLPVKLP DYNSRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK 300
QRPYTFLLPR KCHSVEVQNG KMSTNGVSNG VSNGLHLHSN GFRLPESKGC ISPQVELPPY 360
LERVKQQANE AFACQQWTQA IQLYSQAVQK APHNAMLYGN RAAAYMKRKW DGDHYDALRD 420
CLKAISLNPC HLKAHFRLAR CLFELKYVAE ALECLDDFKG KFPEQAHSSA CDALGRDITA 480
ALFSKSDGEE KKAAGGGGGP VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI 540
KEANFFGRRP PTSSECCRGM SPLSTACSPI PATASWPPVA STLLCDCGTH DQRVKTSQAE 600
LWKIWRVHLR PTSGA 615 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004857; F:enzyme inhibitor activity; IDA:MGI.
 GO:0055082; P:cellular chemical homeostasis; IMP:MGI.
 GO:0032869; P:cellular response to insulin stimulus; IMP:MGI.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0008361; P:regulation of cell size; IMP:MGI. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF07719; TPR_2
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50293; TPR_REGION
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS