UniProt Accession

 DNJA2_MOUSE; Q9QYJ0 

Genbank Protein ID

 AB028853; AK077672; AK083208; BC003420 

Genbank Nucleotide ID

 BAA88301.1; BAC36946.1; BAC38809.1; AAH03420.1 

Protein Name

 DnaJ homolog subfamily A member 2 

Protein Synonyms/Alias

 mDj3 

Gene Name

 Dnaja2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
33	KAYRKLAKEYHPDKN	ubiquitination	[1]
39	AKEYHPDKNPNAGDK	acetylation	[2, 3]
39	AKEYHPDKNPNAGDK	ubiquitination	[1]
46	KNPNAGDKFKEISFA	ubiquitination	[1]
131	LEDLYNGKTTKLQLS	ubiquitination	[1]
134	LYNGKTTKLQLSKNV	ubiquitination	[1]
152	ACSGQGGKSGAVQKC	acetylation	[3]
152	ACSGQGGKSGAVQKC	ubiquitination	[1]
302	VVKYPPGKVIEPGCV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Co-chaperone of Hsc70 (By similarity). 

Sequence Annotation

 DOMAIN 8 70 J.
 REPEAT 143 150 CXXCXGXG motif.
 REPEAT 159 166 CXXCXGXG motif.
 REPEAT 186 193 CXXCXGXG motif.
 REPEAT 202 209 CXXCXGXG motif.
 ZN_FING 130 214 CR-type.
 METAL 143 143 Zinc 1 (By similarity).
 METAL 146 146 Zinc 1 (By similarity).
 METAL 159 159 Zinc 2 (By similarity).
 METAL 162 162 Zinc 2 (By similarity).
 METAL 186 186 Zinc 2 (By similarity).
 METAL 189 189 Zinc 2 (By similarity).
 METAL 202 202 Zinc 1 (By similarity).
 METAL 205 205 Zinc 1 (By similarity).
 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 409 409 Cysteine methyl ester (By similarity).
 LIPID 409 409 S-farnesyl cysteine (By similarity).  

Keyword

 Chaperone; Complete proteome; Direct protein sequencing; Lipoprotein; Membrane; Metal-binding; Methylation; Phosphoprotein; Prenylation; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0009408; P:response to heat; IEA:InterPro. 

Interpro

 IPR012724; DnaJ.
 IPR002939; DnaJ_C.
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR008971; HSP40/DnaJ_pept-bd.
 IPR001305; HSP_DnaJ_Cys-rich_dom. 

Pfam

 PF00226; DnaJ
 PF01556; DnaJ_C
 PF00684; DnaJ_CXXCXGXG 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2
 PS51188; ZF_CR 

PRINTS

 PR00625; JDOMAIN.