CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014159
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-actin-capping protein subunit beta 
Protein Synonyms/Alias
 CapZ beta 
Gene Name
 Capzb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
78YRSPWSNKYDPPLEDacetylation[1]
95MPSARLRKLEVEANNacetylation[1]
223LVEDMENKIRSTLNEacetylation[1]
235LNEIYFGKTKDIVNGacetylation[1]
235LNEIYFGKTKDIVNGubiquitination[2]
252SVQTFADKSKQEALKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 235 235 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Actin capping; Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 272 AA 
Protein Sequence
MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA RDKVVGKDYL 60
LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA NNAFDQYRDL YFEGGVSSVY 120
LWDLDHGFAG VILIKKAGDG SKKIKGCWDS IHVVEVQEKS SGRTAHYKLT STVMLWLQTN 180
KSGSGTMNLG GSLTRQMEKD ETVSDCSPHI ANIGRLVEDM ENKIRSTLNE IYFGKTKDIV 240
NGLRSVQTFA DKSKQEALKN DLVEALKRKQ QC 272 
Gene Ontology
 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB. 
Interpro
 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 
Pfam
 PF01115; F_actin_cap_B 
SMART
  
PROSITE
 PS00231; F_ACTIN_CAPPING_BETA 
PRINTS
 PR00192; FACTINCAPB.