CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein-cysteine N-palmitoyltransferase HHAT 
Protein Synonyms/Alias
 Hedgehog acyltransferase; Melanoma antigen recognized by T-cells 2; MART-2; Skinny hedgehog protein 1 
Gene Name
 HHAT 
Gene Synonyms/Alias
 MART2; SKI1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
156LQGVEEVKRRWYKTEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (By similarity). May bind GTP. 
Sequence Annotation
 REGION 448 455 GTP-binding (Probable).
 ACT_SITE 379 379 Potential.  
Keyword
 Acyltransferase; Alternative splicing; Complete proteome; Developmental protein; Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 60
SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KHRPWILMLY GMWACWCVLG TPGVAMVLLH 120
TTISFCVAQF RSQLLTWLCS LLLLSTLRLQ GVEEVKRRWY KTENEYYLLQ FTLTVRCLYY 180
TSFSLELCWQ QLPAASTSYS FPWMLAYVFY YPVLHNGPIL SFSEFIKQMQ QQEHDSLKAS 240
LCVLALGLGR LLCWWWLAEL MAHLMYMHAI YSSIPLLETV SCWTLGGLAL AQVLFFYVKY 300
LVLFGVPALL MRLDGLTPPA LPRCVSTMFS FTGMWRYFDV GLHNFLIRYV YIPVGGSQHG 360
LLGTLFSTAM TFAFVSYWHG GYDYLWCWAA LNWLGVTVEN GVRRLVETPC IQDSLARYFS 420
PQARRRFHAA LASCSTSMLI LSNLVFLGGN EVGKTYWNRI FIQGWPWVTL SVLGFLYCYS 480
HVGIAWAQTY ATD 493 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0016409; F:palmitoyltransferase activity; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0018345; P:protein palmitoylation; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara. 
Interpro
 IPR004299; MBOAT_fam. 
Pfam
 PF03062; MBOAT 
SMART
  
PROSITE
  
PRINTS