| Tag | Content |
|---|
| CPLM ID | CPLM-018202 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Translocation protein SEC63 homolog |
Protein Synonyms/Alias | |
Gene Name | Sec63 |
Gene Synonyms/Alias | Sec63l |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 147 | VMFMRIAKAYAALTD | ubiquitination | [1] | | 368 | ASLENCMKLSQMAVQ | ubiquitination | [1] | | 381 | VQGLQQFKSPLLQLP | ubiquitination | [1] | | 407 | NHKKYKIKTIQDLVS | ubiquitination | [1] | | 416 | IQDLVSLKESDRHSL | ubiquitination | [1] | | 633 | ALLETKSKITHPVYS | ubiquitination | [1] | | 688 | LKFPAPGKPGNYQYT | ubiquitination | [1] | | 710 | YMGLDQIKPLKLEVH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane (By similarity). |
Sequence Annotation | DOMAIN 104 165 J.
DOMAIN 367 457 SEC63 1.
DOMAIN 637 714 SEC63 2.
MOD_RES 307 307 Phosphoserine.
MOD_RES 593 593 Phosphoserine.
MOD_RES 597 597 Phosphoserine.
MOD_RES 742 742 Phosphoserine (By similarity).
MOD_RES 748 748 Phosphoserine (By similarity). |
Keyword | Chaperone; Coiled coil; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 760 AA |
Protein Sequence | MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR KVYGRCMWYR 60
LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY QEYNPYEVLN LDPGATVAEI 120
KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA ALTDEESRKN WEEFGNPDGP QATSFGIALP 180
AWIVDQKNSI LVLLVYGLAF MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN 240
MDMKRLIMVL AGASEFDPQY NKDSTSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK 300
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIIMARSR EEREFRAPTL 360
ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN HKKYKIKTIQ DLVSLKESDR 420
HSLLHFLEDE KYEEVMAVLG SFPYVTMDIK SQVLDDEDSN NITVGSLVTV LVKLTRQTMA 480
EVFEKEQSIC AAEEQPTEDG QSDANKIKAK GGWQQKNKGP KKMPKSKKKK PLKKKPTTVP 540
LPQAKQQKQK QANGVVGSEA AIKEEEDDIS DKGSDSEEEE TNRDSQSEKE DGSDRESDRE 600
QDEKQSKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW WWLYIADRKE 660
QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS DSYMGLDQIK PLKLEVHEAK 720
PVPENHPQWD TAIEGDEDQE DSEGFEDSFE EEEEEEEGGD 760 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0008565; F:protein transporter activity; IEA:InterPro. GO:0001889; P:liver development; IMP:MGI. GO:0010259; P:multicellular organismal aging; IMP:MGI. GO:0006807; P:nitrogen compound metabolic process; IGI:MGI. GO:0031204; P:posttranslational protein targeting to membrane, translocation; IEA:InterPro. GO:0072001; P:renal system development; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |