CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009378
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-2-microglobulin 
Protein Synonyms/Alias
 Beta-2-microglobulin form pI 5.3 
Gene Name
 B2M 
Gene Synonyms/Alias
 CDABP0092; HDCMA22P 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26EAIQRTPKIQVYSRHglycation[1]
26EAIQRTPKIQVYSRHubiquitination[2]
39RHPAENGKSNFLNCYglycation[3]
39RHPAENGKSNFLNCYubiquitination[2]
61DIEVDLLKNGERIEKglycation[3]
61DIEVDLLKNGERIEKubiquitination[2]
68KNGERIEKVEHSDLSglycation[3, 4]
78HSDLSFSKDWSFYLLglycation[3]
111HVTLSQPKIVKWDRDglycation[3]
114LSQPKIVKWDRDM**glycation[1, 3]
114LSQPKIVKWDRDM**ubiquitination[2]
Reference
 [1] Identity and localization of advanced glycation end products on human beta2-microglobulin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
 Cocklin RR, Zhang Y, O'Neill KD, Chen NX, Moe SM, Bidasee KR, Wang M.
 Anal Biochem. 2003 Mar 15;314(2):322-5. [PMID: 12654321]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites.
 Miyata T, Inagi R, Wada Y, Ueda Y, Iida Y, Takahashi M, Taniguchi N, Maeda K.
 Biochemistry. 1994 Oct 11;33(40):12215-21. [PMID: 7918443]
 [4] Beta2-microglobulin causes abnormal phosphatidylserine exposure in human red blood cells.
 Pavone B, Bucci S, Sirolli V, Merlini G, Del Boccio P, Di Rienzo M, Felaco P, Amoroso L, Sacchetta P, Di Ilio C, Federici G, Urbani A, Bonomini M.
 Mol Biosyst. 2011 Mar;7(3):651-8. [PMID: 21107472] 
Functional Description
 Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. 
Sequence Annotation
 DOMAIN 25 113 Ig-like C1-type.
 MOD_RES 22 22 Pyrrolidone carboxylic acid; in form pI
 CARBOHYD 21 21 N-linked (Glc) (glycation); in
 CARBOHYD 39 39 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 61 61 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 68 68 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 78 78 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 111 111 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 114 114 N-linked (Glc) (glycation); in vitro.
 DISULFID 45 100  
Keyword
 3D-structure; Amyloid; Amyloidosis; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycation; Glycoprotein; Immunity; Immunoglobulin domain; MHC I; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 119 AA 
Protein Sequence
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL 60
KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM 119 
Gene Ontology
 GO:0031905; C:early endosome lumen; TAS:Reactome.
 GO:0031901; C:early endosome membrane; TAS:Reactome.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.
 GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Compara.
 GO:0042026; P:protein refolding; IEA:Compara.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0002237; P:response to molecule of bacterial origin; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0016032; P:viral reproduction; TAS:Reactome. 
Interpro
 IPR015707; B2Microglobulin.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 
Pfam
 PF07654; C1-set 
SMART
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE
 PS00290; IG_MHC 
PRINTS