CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037255
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase Lck 
Protein Synonyms/Alias
  
Gene Name
 LCK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
143EQSGEWWKAQSLTTGubiquitination[1]
174EPEPWFFKNLSRKDAubiquitination[1, 2, 3]
223QNQGEVVKHYKIRNLacetylation[3]
223QNQGEVVKHYKIRNLubiquitination[1, 2, 3]
226GEVVKHYKIRNLDNGubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MGIPGSHNLR YFWNFPGQGP IISDVGGADL GGAPSAPSSI PSGTMGCGCS SHPEDDWMEN 60
IDVCENCHYP IVPLDGKGTL LIRNGSEVRD PLVTYEGSNP PASPLQDNLV IALHSYEPSH 120
DGDLGFEKGE QLRILEQSGE WWKAQSLTTG QEGFIPFNFV AKANSLEPEP WFFKNLSRKD 180
AERQLLAPGN THGSFLIRES ESTAGSFSLS VRDFDQNQGE VVKHYKIRNL DNGGFYISPR 240
ITFPGLHELV RHYTNASDGL CTRLSRPCQT QKPQKPWWED EWEVP 285 
Gene Ontology
  
Interpro
 IPR000980; SH2.
 IPR001452; SH3_domain. 
Pfam
 PF00017; SH2
 PF00018; SH3_1 
SMART
 SM00252; SH2
 SM00326; SH3 
PROSITE
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.