| Tag | Content |
|---|
| CPLM ID | CPLM-023829 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Plexin-D1 |
Protein Synonyms/Alias | |
Gene Name | PLXND1 |
Gene Synonyms/Alias | KIAA0620 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 251 | DTRGDLAKLFTFDLN | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. |
Sequence Annotation | DOMAIN 47 546 Sema.
DOMAIN 891 979 IPT/TIG 1.
DOMAIN 981 1066 IPT/TIG 2.
DOMAIN 1069 1160 IPT/TIG 3.
CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
CARBOHYD 155 155 N-linked (GlcNAc...) (Potential).
CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
CARBOHYD 224 224 N-linked (GlcNAc...) (Potential).
CARBOHYD 481 481 N-linked (GlcNAc...) (Potential).
CARBOHYD 500 500 N-linked (GlcNAc...).
CARBOHYD 583 583 N-linked (GlcNAc...) (Potential).
CARBOHYD 696 696 N-linked (GlcNAc...) (Potential).
CARBOHYD 736 736 N-linked (GlcNAc...) (Potential).
CARBOHYD 802 802 N-linked (GlcNAc...) (Potential).
CARBOHYD 965 965 N-linked (GlcNAc...) (Potential).
CARBOHYD 1017 1017 N-linked (GlcNAc...) (Potential).
CARBOHYD 1060 1060 N-linked (GlcNAc...) (Potential).
CARBOHYD 1099 1099 N-linked (GlcNAc...) (Potential).
CARBOHYD 1118 1118 N-linked (GlcNAc...) (Potential).
CARBOHYD 1132 1132 N-linked (GlcNAc...) (Potential).
CARBOHYD 1237 1237 N-linked (GlcNAc...) (Potential).
CARBOHYD 1257 1257 N-linked (GlcNAc...) (Potential).
DISULFID 104 114 By similarity.
DISULFID 140 148 By similarity.
DISULFID 322 445 By similarity.
DISULFID 345 389 By similarity.
DISULFID 549 566 By similarity.
DISULFID 555 600 By similarity.
DISULFID 558 575 By similarity.
DISULFID 569 581 By similarity.
DISULFID 637 661 By similarity. |
Keyword | 3D-structure; Alternative splicing; Angiogenesis; Cell membrane; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1925 AA |
Protein Sequence | MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ RRFPSPTPTN 60
NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD SPLCHAPQLP QASCEHPRRL 120
TDNYNKILQL DPGQGLVVVC GSIYQGFCQL RRRGNISAVA VRFPPAAPPA EPVTVFPSML 180
NVAANHPNAS TVGLVLPPAA GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI 240
RSLDTRGDLA KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA 300
LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG RGDLYSRLVS 360
VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI RAARTACFVE PAPDVVAVLD 420
SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL QHPLSILQPL KATPVFRAPG LTSVAVASVN 480
NYTAVFLGTV NGRLLKINLN ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ 540
MARVKVAACN VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC 600
PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP GPAFGHQIAY 660
CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY DCSRTAQVYP HTACTSCLSA 720
QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ DCPRTLLSPL APVPTGGSQN ILVPLANTAF 780
FQGAALECSF GLEEIFEAVW VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE 840
PMTVMVYNCA MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS 900
GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV TGPAPGPLSG 960
VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT IHGNDLHVGS ELQVLVNDTD 1020
PCTELMRTDT SIACTMPEGA LPAPVPVCVR FERRGCVHGN LTFWYMQNPV ITAISPRRSP 1080
VSGGRTITVA GERFHMVQNV SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF 1140
INGRAYADEV AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1200
KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT IQVGNFNQTI 1260
ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE 1320
EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSQTLNS 1380
QGSSQAQETH PLLGEWKIPE SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD 1440
RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1500
CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN IEAKPRNLNV 1560
SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYIL 1620
RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT 1680
DELAEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF 1740
FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ 1800
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE QEMNAHLAEE 1860
SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMEDNIYE 1920
CYSEA 1925 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. GO:0005622; C:intracellular; IEA:InterPro. GO:0017154; F:semaphorin receptor activity; ISS:UniProtKB. GO:0001525; P:angiogenesis; ISS:UniProtKB. GO:0007411; P:axon guidance; TAS:Reactome. GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IEA:Compara. GO:0043542; P:endothelial cell migration; ISS:UniProtKB. GO:0001569; P:patterning of blood vessels; IEA:Compara. GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB. GO:0030334; P:regulation of cell migration; ISS:UniProtKB. GO:0007416; P:synapse assembly; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |