UniProt Accession

 STX8_RAT; Q9Z2Q7 

Genbank Protein ID

 AF033109 

Genbank Nucleotide ID

 AAC70903.1 

Protein Name

 Syntaxin-8 

Protein Synonyms/Alias

  

Gene Name

 Stx8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
49	LTIRTLLKNLKVKID	acetylation	[1]
98	RLLLASFKNEGSEPD	acetylation	[1]
98	RLLLASFKNEGSEPD	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. 

Sequence Annotation

 DOMAIN 145 207 t-SNARE coiled-coil homology.  

Keyword

 3D-structure; Coiled coil; Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IDA:RGD.
 GO:0005765; C:lysosomal membrane; IDA:RGD.
 GO:0031201; C:SNARE complex; IDA:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; IDA:RGD.
 GO:0006906; P:vesicle fusion; IDA:RGD. 

Interpro

 IPR015640; Syntax_8.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS