UniProt Accession

 GPX1_BOVIN; P00435; A6QPG3 

Genbank Protein ID

 X13684; BC149308 

Genbank Nucleotide ID

 CAB40806.1; AAI49309.1 

Protein Name

 Glutathione peroxidase 1 

Protein Synonyms/Alias

 GPx-1; GSHPx-1; Cellular glutathione peroxidase 

Gene Name

 GPX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
117	PNFMLFEKCEVNGEK	glycation	[1]

Reference

 [1] Identification of the site of non-enzymatic glycation of glutathione peroxidase: rationalization of the glycation-related catalytic alterations on the basis of three-dimensional protein structure.
 Baldwin JS, Lee L, Leung TK, Muruganandam A, Mutus B.
 Biochim Biophys Acta. 1995 Feb 22;1247(1):60-4. [PMID: 7873592] 

Functional Description

 Protects the hemoglobin in erythrocytes from oxidative breakdown. 

Sequence Annotation

 ACT_SITE 52 52
 MOD_RES 151 151 N6-acetyllysine (By similarity).
 CARBOHYD 117 117 N-linked (Glc) (glycation); in vitro.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Glycation; Glycoprotein; Oxidoreductase; Peroxidase; Reference proteome; Selenocysteine. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004602; F:glutathione peroxidase activity; IEA:EC.
 GO:0006979; P:response to oxidative stress; IEA:InterPro. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.