| Tag | Content |
|---|
| CPLM ID | CPLM-017222 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphofurin acidic cluster sorting protein 1 |
Protein Synonyms/Alias | PACS-1 |
Gene Name | Pacs1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 187 | FLKRDANKLQIMLQR | ubiquitination | [1] | | 337 | QKFVALLKRFKVSDE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 28 28 Phosphoserine.
MOD_RES 249 249 Phosphotyrosine.
MOD_RES 377 377 Phosphoserine (By similarity).
MOD_RES 427 427 Phosphothreonine.
MOD_RES 428 428 Phosphoserine (By similarity).
MOD_RES 502 502 Phosphothreonine (By similarity).
MOD_RES 527 527 Phosphoserine (By similarity).
MOD_RES 529 529 Phosphoserine (By similarity).
MOD_RES 532 532 Phosphoserine (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; Golgi apparatus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 961 AA |
Protein Sequence | MAERGGAGGG PGGSGGGSSQ RGSGVAQSPQ QQPQQQPPQP QQPTPPKLAQ ATSSSSSTSA 60
AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN LYATWEVDRS SSSCVPRLFS 120
LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR ILRSNEIILP ASGLVETELQ LTFSLQYPHF 180
LKRDANKLQI MLQRRKRYKN RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS 240
VPVAEIKIYS LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF 300
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE HVSREQIREV 360
EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF FEGMSQSSSQ TEIGSLNSKG 420
SLGKDTTSPM ELAALEKVKS TWIKNQDDSL TETDTLEITD QDMFGDVSTS LVVPEKVKTP 480
MKSSKADLQG SASPSKVEGT HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ 540
IPRKVVYDQL NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV 600
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD WLGYMRFLII 660
PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE PLDVVGRVMQ YVNGATTTHQ 720
LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP 780
PSSSGLSRDA TATPPSSPSM SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD 840
ASSKNTLKSV FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS 900
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF PVGLFSGSKT 960
T 961 |
Gene Ontology | GO:0030137; C:COPI-coated vesicle; IDA:MGI. GO:0000042; P:protein targeting to Golgi; IDA:MGI. GO:0072661; P:protein targeting to plasma membrane; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |