UniProt Accession

 YPD1_YEAST; Q07688; D6VRC1 

Genbank Protein ID

 U62016; Z74283; BK006938 

Genbank Nucleotide ID

 AAC49440.1; CAA98815.1; DAA11631.1 

Protein Name

 Phosphorelay intermediate protein YPD1 

Protein Synonyms/Alias

 Histidine-containing phosphotransfer protein YPD1; Tyrosine phosphatase-dependent protein 1 

Gene Name

 YPD1 

Gene Synonyms/Alias

 YDL235C; D0790 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
161	LARIELSKYYNTNL*	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus. 

Sequence Annotation

 DOMAIN 24 129 HPt.
 MOD_RES 64 64 Phosphohistidine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IDA:SGD.
 GO:0007234; P:osmosensory signaling via phosphorelay pathway; IDA:SGD. 

Interpro

 IPR008207; Sig_transdc_His_kin_Hpt_dom. 

Pfam

 PF01627; Hpt 

SMART

 SM00073; HPT 

PROSITE

 PS50894; HPT 

PRINTS