UniProt Accession

 CATB_MOUSE; P10605; Q3UDW7 

Genbank Protein ID

 M65270; M65263; M65264; M65265; M65266; M65267; M65268; M65269; M14222; X54966; S69034; AK083393; AK147192; AK149884; AK151790; AK167361; BC006656 

Genbank Nucleotide ID

 AAA37375.1; AAA37375.1; AAA37375.1; AAA37375.1; AAA37375.1; AAA37375.1; AAA37375.1; AAA37375.1; AAA37494.1; CAA38713.1; AAB20536.1; BAC38900.1; BAE27751.1; BAE29144.1; BAE30691.1; BAE39458.1; AAH06656.1 

Protein Name

 Cathepsin B 

Protein Synonyms/Alias

 Cathepsin B1; Cathepsin B light chain; Cathepsin B heavy chain 

Gene Name

 Ctsb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
220	AGYSPSYKEDKHFGY	acetylation	[1, 2, 3, 4]
220	AGYSPSYKEDKHFGY	ubiquitination	[5]
223	SPSYKEDKHFGYTSY	acetylation	[1]
245	EIMAEIYKNGPVEGA	acetylation	[4]
268	TYKSGVYKHEAGDMM	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. 

Sequence Annotation

 ACT_SITE 108 108 By similarity.
 ACT_SITE 278 278 By similarity.
 ACT_SITE 298 298 By similarity.
 CARBOHYD 192 192 N-linked (GlcNAc...) (Probable).
 DISULFID 93 122 By similarity.
 DISULFID 105 150 By similarity.
 DISULFID 141 207 By similarity.
 DISULFID 142 146 By similarity.
 DISULFID 179 211 By similarity.
 DISULFID 187 198 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Secreted; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0050790; P:regulation of catalytic activity; IEA:InterPro. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR015643; Peptidase_C1A_cathepsin-B.
 IPR012599; Propeptide_C1A. 

Pfam

 PF00112; Peptidase_C1
 PF08127; Propeptide_C1 

SMART

 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.