UniProt Accession

 GRPE1_HUMAN; Q9HAV7; B2R783; Q549M6 

Genbank Protein ID

 AK312882; AF298592; AF087896; AL542571; CH471131; BC024242 

Genbank Nucleotide ID

 BAG35730.1; AAG31605.1; AAP97195.1; EAW82371.1; AAH24242.1 

Protein Name

 GrpE protein homolog 1, mitochondrial 

Protein Synonyms/Alias

 HMGE; Mt-GrpE#1 

Gene Name

 GRPEL1 

Gene Synonyms/Alias

 GREPEL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	DMGQSEQKADPPATE	ubiquitination	[1]
66	TLLEEKVKLEEQLKE	acetylation	[2]
72	VKLEEQLKETVEKYK	ubiquitination	[1]
94	NLRQRSQKLVEEAKL	acetylation	[2]
157	QIQKVFTKHGLLKLN	acetylation	[2, 3]
215	PALVGVVKEA*****	acetylation	[3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. 

Sequence Annotation

 MOD_RES 215 215 N6-acetyllysine.  

Keyword

 Acetylation; Chaperone; Complete proteome; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
 GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0051082; F:unfolded protein binding; IDA:UniProtKB.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0030150; P:protein import into mitochondrial matrix; NAS:UniProtKB. 

Interpro

 IPR000740; GrpE.
 IPR013805; GrpE_coiled_coil.
 IPR009012; GrpE_head. 

Pfam

 PF01025; GrpE 

SMART

  

PROSITE

 PS01071; GRPE 

PRINTS

 PR00773; GRPEPROTEIN.