CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Claudin-11 
Protein Synonyms/Alias
 Oligodendrocyte transmembrane protein; Oligodendrocyte-specific protein 
Gene Name
 Cldn11 
Gene Synonyms/Alias
 Osp; Otm 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
203SSSPTHAKSAHV***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). 
Sequence Annotation
 MOD_RES 197 197 Phosphoserine.
 MOD_RES 198 198 Phosphoserine.  
Keyword
 Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MVATCLQVVG FVTSFVGWIG IIVTTSTNDW VVTCSYTIPT CRKMDELGSK GLWADCVMAT 60
GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL TVLPCIRMGH EPGVAKYRRA 120
QLAGVLLILL ALCAIVATIW FPVCAHREIT IVSFGYSLYA GWIGAVMCLV GGCVIVCCSG 180
DAQSFGENRF YYSSGSSSPT HAKSAHV 207 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0005923; C:tight junction; ISS:UniProtKB.
 GO:0042802; F:identical protein binding; ISS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0008366; P:axon ensheathment; IMP:MGI.
 GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; IMP:MGI. 
Interpro
 IPR006187; Claudin.
 IPR003555; Claudin11.
 IPR017974; Claudin_CS.
 IPR004031; PMP22/EMP/MP20/Claudin. 
Pfam
 PF00822; PMP22_Claudin 
SMART
  
PROSITE
 PS01346; CLAUDIN 
PRINTS
 PR01077; CLAUDIN.
 PR01384; CLAUDIN11.