CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040033
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Regulatory-associated protein of mTOR 
Protein Synonyms/Alias
  
Gene Name
 RPTOR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43CEKIEGSKSLAQSWRubiquitination[1]
97PLSMGPQKALETIGAubiquitination[1]
108TIGANLQKQYENWQPubiquitination[1, 2, 3, 4]
120WQPRARYKQSLDPTVubiquitination[1, 2, 5]
131DPTVDEVKKLCTSLRubiquitination[1, 2]
682VLNSIAYKATVNARPubiquitination[1]
774RTRKMFDKGPEQTADubiquitination[1]
815YFAQPVMKIPEEHDLubiquitination[2]
850QAQQVIQKGITRLDDubiquitination[1, 2, 3, 4, 5]
898WDWEKGEKLDYFHNGubiquitination[2]
939DGAIRVWKNFADLEKubiquitination[2, 6]
999WDTDREMKVQDIPTGubiquitination[1]
1063VVKASLQKRPDGHIVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1177 AA 
Protein Sequence
MESEMLQSPL LGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR MKDRMKTVSV 60
ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE TIGANLQKQY ENWQPRARYK 120
QSLDPTVDEV KKLCTSLRRN AKEERVLFHY NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY 180
DLQTWMGSPS IFVYDCSNAG LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC 240
IQLAACEATE LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG 300
RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF LLAERIMRSY 360
NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG TAFRHSPFFA EQLTAFQVWL 420
TMGVENRNPP EQLPIVLQVL LSQVHRLRAL DLLGRFLDLG PWAVSLALSV GIFPYVLKLL 480
QSSARELRPL LVFIWAKILA VDSELVVALS HLVVQYESNF CTVALQFIEE EKNYALPSPA 540
TTEGGSLTPV RDSPCTPRLR SVSSYGNIRA VATARSLNKS LQNLSLTEES GGAVAFSPGN 600
LSTSSSASST LGSPENEEHI LSFETIDKMR RASSYSSLNS LIGVSFNSVY TQIWRVLLHL 660
AADPYPEVSD VAMKVLNSIA YKATVNARPQ RVLDTSSLTQ SAPASPTNKG VHIHQAGGSP 720
PASSTSSSSL TNDVAKQPVS RDLPSGRPGT TGPAGAQYTP HSHQFPRTRK MFDKGPEQTA 780
DDADDAAGHK SFISATVQTG FCDWSARYFA QPVMKIPEEH DLESQIRKER EWRFLRNSRV 840
RRQAQQVIQK GITRLDDQIF LNRNPGVPSV VKFHPFTPCI AVADKDSICF WDWEKGEKLD 900
YFHNGNPRYT RVTAMEYLNG QDCSLLLTAT DDGAIRVWKN FADLEKNPEM VTAWQGLSDM 960
LPTTRGAGMV VDWEQETGLL MSSGDVRIVR IWDTDREMKV QDIPTGADSC VTSLSCDSHR 1020
SLIVAGLGDG SIRVYDRRMA LSECRVMTYR EHTAWVVKAS LQKRPDGHIV SVSVNGDVRI 1080
FDPRMPESVN VLQIVKGLTA LDIHPQADLI ACGSVNQFTA IYNSSGELIN NIKYYDGFMG 1140
QRVGAISCLA FHPHWPHLAV GSNDYYISVY SVEKRVR 1177 
Gene Ontology
 GO:0031931; C:TORC1 complex; IEA:InterPro.
 GO:0031929; P:TOR signaling cascade; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR004083; Raptor.
 IPR027466; Raptor_metazoan.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR01547; YEAST176DUF.