CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 40S ribosomal protein S17 
Protein Synonyms/Alias
  
Gene Name
 Rps17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19AARVIIEKYYTRLGNacetylation[1, 2, 3, 4, 5]
19AARVIIEKYYTRLGNsuccinylation[4]
19AARVIIEKYYTRLGNubiquitination[6]
49PSKKLRNKIAGYVTHacetylation[4]
49PSKKLRNKIAGYVTHubiquitination[6]
72PVRGISIKLQEEEREubiquitination[6]
103IEVDPDTKEMLKLLDubiquitination[6]
107PDTKEMLKLLDFGSLubiquitination[6, 7]
129PTVGMNFKTPRGAV*ubiquitination[6]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [7] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144
Functional Description
  
Sequence Annotation
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 130 130 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 135 AA 
Protein Sequence
MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR 60
IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT 120
QPTVGMNFKT PRGAV 135 
Gene Ontology
 GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
 GO:0003735; F:structural constituent of ribosome; ISO:MGI.
 GO:0000028; P:ribosomal small subunit assembly; IBA:RefGenome.
 GO:0006414; P:translational elongation; IBA:RefGenome. 
Interpro
 IPR001210; Ribosomal_S17e.
 IPR018273; Ribosomal_S17e_CS. 
Pfam
 PF00833; Ribosomal_S17e 
SMART
  
PROSITE
 PS00712; RIBOSOMAL_S17E 
PRINTS