CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002959
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase 
Protein Synonyms/Alias
 UDP-N-acetylglucosamine acyltransferase 
Gene Name
 lpxA 
Gene Synonyms/Alias
 b0181; JW0176 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
76GEVNQDLKYAGEPTRacetylation[1]
220TAIRNAYKLIYRSGKacetylation[1]
227KLIYRSGKTLDEVKPacetylation[1]
233GKTLDEVKPEIAELAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. 
Sequence Annotation
 REGION 73 76 Substrate binding.
 BINDING 125 125 Substrate.
 BINDING 144 144 Substrate.
 BINDING 161 161 Substrate.  
Keyword
 3D-structure; Acyltransferase; Complete proteome; Cytoplasm; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 262 AA 
Protein Sequence
MIDKSAFVHP TAIVEEGASI GANAHIGPFC IVGPHVEIGE GTVLKSHVVV NGHTKIGRDN 60
EIYQFASIGE VNQDLKYAGE PTRVEIGDRN RIRESVTIHR GTVQGGGLTK VGSDNLLMIN 120
AHIAHDCTVG NRCILANNAT LAGHVSVDDF AIIGGMTAVH QFCIIGAHVM VGGCSGVAQD 180
VPPYVIAQGN HATPFGVNIE GLKRRGFSRE AITAIRNAYK LIYRSGKTLD EVKPEIAELA 240
ETYPEVKAFT DFFARSTRGL IR 262 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0008780; F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity; IDA:EcoliWiki.
 GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR001451; Hexapep_transf.
 IPR018357; Hexapep_transf_CS.
 IPR010137; Lipid_A_LpxA.
 IPR011004; Trimer_LpxA-like. 
Pfam
 PF00132; Hexapep 
SMART
  
PROSITE
 PS00101; HEXAPEP_TRANSFERASES 
PRINTS