CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-CoA dehydrogenase family member 10 
Protein Synonyms/Alias
 ACAD-10 
Gene Name
 Acad10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
272IPQDALEKYLKGLLGacetylation[1]
413TSLDSFGKQGDYIPRacetylation[2, 3]
413TSLDSFGKQGDYIPRsuccinylation[3]
427RQVQTWTKQYRAAETacetylation[1, 2, 3, 4]
427RQVQTWTKQYRAAETsuccinylation[3]
522FRDQDVTKLGIPTVEacetylation[4]
1052VHQLTVAKMELKNQSacetylation[1, 2, 3, 5]
1052VHQLTVAKMELKNQSsuccinylation[3]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
 Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA (By similarity). 
Sequence Annotation
 NP_BIND 792 802 FAD (By similarity).
 BINDING 828 828 FAD (By similarity).
 BINDING 943 943 FAD (By similarity).
 BINDING 1013 1013 FAD (By similarity).
 BINDING 1044 1044 FAD (By similarity).  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1069 AA 
Protein Sequence
MLVRRLFQPS TLHWAWRTTA LNHPLGRHQG GLRWTHSGGR SYRAVIFDTG GVLVPSPGTV 60
AVGWEVQNHV PSGTIVKAFI RGGDSGPWIR FIKGEITTEH FLEEFGRLCS EIAKTSVPVS 120
SYFSLLTSEQ VTKQFPVMTQ AISQIRAKGL QTAVLTNNFH LSSGESFLPL DRKQFDVVVE 180
SCLEGICKPD PRIFQLCLQR LSLQPSEAIF LDDLGSNLKV AASLGIHTIK VDRPETAVKE 240
LEALLGFPLH LGVPNTRPVR KTMAIPQDAL EKYLKGLLGT HSTGPMELLQ FDHGQSNPTY 300
YIRLADRQLV LRKKPSGTLL PSAHAIEREF RIMKALANAG VPVPTVLDLC EDSSIIGTPF 360
YLMEYCPGII YKDPSLPGLE PSRREAIYTA MNQVLCRIHS VDLQATSLDS FGKQGDYIPR 420
QVQTWTKQYR AAETSSIPAM ERLIQWLPLH LPRQQRTTLV HGDFRLDNLI FHPEKAEVLA 480
VLDWELSTLG DPFADVAYSC LAYYLPSSFP ILRGFRDQDV TKLGIPTVEE YFRMYCLNMG 540
IPPIDNWNFY MAFSFFRVAA ILQGVYKRSL TGQASSATAQ QSGKLTESMA ELAWDFATKE 600
GFRVFKEMPA TKTLSRSYHA WAGPRSPRTP KGVRGHSTVA AASPSHEAKG GLVISPEGLS 660
PAVRKLYEQL VQFIEQKVYP LEPELQRHQA SADRWSPSPL IEDLKEKAKA EGLWNLFLPL 720
ETDPEKKYGA GLTNVEYAHL CEVMGMSLYA SEIFNCSAPD TGNMEILVRY GTEEQKARWL 780
VPLLEGRIRS CFAMTEPQVA SSDASNIEAS IKEEDGCYVI NGHKWWTSGI LDPRCKLCVF 840
MGKTDPQAPR HQQQSMLLVP MDSPGITVIR PLSVFGLEDP PGGHGEVRFK DVRVPKENIL 900
LGPGRGFEIA QGRLGPGRIH HCMRLIGYSE RALALMKTRV MSRTAFGKPL VEQGTILADI 960
ARSRVEIEQA RLLVLKAAHL MDVAGNKTAA LDIAMIKMVV PSMAYHVIDR AIQAFGAAGL 1020
SSDYPLAQFF GWARALRFAD GPDEVHQLTV AKMELKNQSR MQEPAVPRV 1069 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro. 
Interpro
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase.
 IPR002575; Aminoglycoside_PTrfase.
 IPR023214; HAD-like_dom.
 IPR006402; HAD-SF_hydro_IA_v3.
 IPR011945; HAD-SF_ppase_IA/epoxid_hydro_N.
 IPR005833; Haloacid_DH/epoxide_hydro.
 IPR011009; Kinase-like_dom.
 IPR023198; PGP_dom2. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N
 PF01636; APH
 PF13419; HAD_2 
SMART
  
PROSITE
 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 
PRINTS
 PR00413; HADHALOGNASE.