UniProt Accession

 PDCD6_HUMAN; O75340; B2RD16; E7ESR3; Q2YDC2; Q5TZS0 

Genbank Protein ID

 AF035606; U58773; AK315370; BT020072; AC010442; AC021087; AC118458; CH471235; BC012384; BC106706; BC110291; CB991882 

Genbank Nucleotide ID

 AAC27697.1; AAF14336.1; BAG37763.1; AAV38875.1; EAW50991.1; AAH12384.1; AAI06707.1; AAI10292.1 

Protein Name

 Programmed cell death protein 6 

Protein Synonyms/Alias

 Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2 

Gene Name

 PDCD6 

Gene Synonyms/Alias

 ALG2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	DNSGMIDKNELKQAL	ubiquitination	[1]
116	MIDKNELKQALSGFG	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. 

Sequence Annotation

 DOMAIN 23 58 EF-hand 1.
 DOMAIN 59 89 EF-hand 2.
 DOMAIN 90 125 EF-hand 3.
 DOMAIN 126 161 EF-hand 4.
 DOMAIN 162 191 EF-hand 5.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Calcium; Complete proteome; Endoplasmic reticulum; Membrane; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0060090; F:binding, bridging; IMP:UniProtKB.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0097190; P:apoptotic signaling pathway; TAS:ProtInc.
 GO:0033554; P:cellular response to stress; IDA:UniProtKB.
 GO:0006886; P:intracellular protein transport; IDA:UniProtKB.
 GO:0051592; P:response to calcium ion; ISS:UniProtKB. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS