CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001628
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 YEATS domain-containing protein 4 
Protein Synonyms/Alias
 Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1 
Gene Name
 YEATS4 
Gene Synonyms/Alias
 GAS41 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17PDSGGRVKGVTIVKPubiquitination[1]
64EDMSAYVKKIQFKLHubiquitination[2]
131DTNAMLGKKTVVSEFubiquitination[2, 3, 4]
167QLTLGAYKHETEFAEubiquitination[1]
188EKLEAAKKKTSFEIAubiquitination[1]
189KLEAAKKKTSFEIAEubiquitination[1]
198SFEIAELKERLKASRubiquitination[1, 2]
212RETINCLKNEIRKLEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. 
Sequence Annotation
 DOMAIN 22 126 YEATS.
 REGION 163 227 Interaction with MLLT10.
 REGION 168 227 Interaction with TACC1.  
Keyword
 Chromatin regulator; Coiled coil; Complete proteome; Direct protein sequencing; Growth regulation; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 227 AA 
Protein Sequence
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY VKPYRNEDMS 60
AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII KIFFIDPNER PVTLYHLLKL 120
FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM MQQLLTTSRQ LTLGAYKHET EFAELEVKTR 180
EKLEAAKKKT SFEIAELKER LKASRETINC LKNEIRKLEE DDQAKDI 227 
Gene Ontology
 GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB.
 GO:0016363; C:nuclear matrix; NAS:UniProtKB.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0005200; F:structural constituent of cytoskeleton; NAS:UniProtKB.
 GO:0043968; P:histone H2A acetylation; IDA:UniProtKB.
 GO:0043967; P:histone H4 acetylation; IDA:UniProtKB.
 GO:0007067; P:mitosis; NAS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR005033; YEATS. 
Pfam
 PF03366; YEATS 
SMART
  
PROSITE
 PS51037; YEATS 
PRINTS