UniProt Accession

 ZRAB2_RAT; O35986; A1A4C8 

Genbank Protein ID

 AF013965; AF013966; AF013967; BC087012 

Genbank Nucleotide ID

 AAC02295.1; AAC02296.1; AAC02297.1; AAH87012.1 

Protein Name

 Zinc finger Ran-binding domain-containing protein 2 

Protein Synonyms/Alias

 Zinc finger protein 265; Zinc finger, splicing 

Gene Name

 Zranb2 

Gene Synonyms/Alias

 Zfp265; Zis; Znf265 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MSTKNFRVSDG	acetylation	[1]
43	REKTTEAKMMKAGGT	acetylation	[1]
54	AGGTEIGKTLAEKSR	acetylation	[1]
59	IGKTLAEKSRGLFSA	acetylation	[1]
146	VGPASILKEVEDKES	acetylation	[1]
168	DEDLSKYKLDEDEDE	acetylation	[1]
195	SEEEDSNKKKSNRRS	acetylation	[1]
196	EEEDSNKKKSNRRSR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'- splice site selection (By similarity). 

Sequence Annotation

 ZN_FING 9 40 RanBP2-type 1.
 ZN_FING 65 94 RanBP2-type 2.
 REGION 151 324 Required for nuclear targeting (By
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 54 54 N6-acetyllysine (By similarity).
 MOD_RES 114 114 Phosphotyrosine (By similarity).
 MOD_RES 120 120 Phosphoserine (By similarity).
 MOD_RES 153 153 Phosphoserine.
 MOD_RES 181 181 Phosphoserine (By similarity).
 MOD_RES 188 188 Phosphoserine (By similarity).
 MOD_RES 193 193 Phosphoserine (By similarity).
 MOD_RES 290 290 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:RGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR017337; UCP037956_Znf_RanB2.
 IPR001876; Znf_RanBP2. 

Pfam

 PF00641; zf-RanBP 

SMART

 SM00547; ZnF_RBZ 

PROSITE

 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 

PRINTS