CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019259
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coiled-coil domain-containing protein 104 
Protein Synonyms/Alias
  
Gene Name
 CCDC104 
Gene Synonyms/Alias
 UNQ163/PRO189 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88EYKELVEKLLEGYLKubiquitination[1, 2, 3, 4]
95KLLEGYLKEIGINEDubiquitination[2]
114ACTSPLAKTHTSQAIubiquitination[2, 3]
135AEDFTIFKAMMVQKNubiquitination[2]
141FKAMMVQKNIEMQLQubiquitination[1, 2, 3, 4, 5]
180DLEHEEMKILREVLRubiquitination[2]
307YLKQKRDKLMSMRKDubiquitination[1, 2, 4]
318MRKDMRTKQIQNMEQubiquitination[1, 2, 3, 4]
328QNMEQKGKPTGEVEEubiquitination[3]
352EEKQTLLKRRLLAEKubiquitination[2]
359KRRLLAEKLKEEVINubiquitination[2, 4, 5]
361RLLAEKLKEEVINK*ubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
 May act as an effector for ARL3. 
Sequence Annotation
  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
MAAEEEDEVE WVVESIAGFL RGPDWSIPIL DFVEQKCEVN CKGGHVITPG SPEPVILVAC 60
VPLVFDDEEE SKLTYTEIHQ EYKELVEKLL EGYLKEIGIN EDQFQEACTS PLAKTHTSQA 120
ILQPVLAAED FTIFKAMMVQ KNIEMQLQAI RIIQERNGVL PDCLTDGSDV VSDLEHEEMK 180
ILREVLRKSK EEYDQEEERK RKKQLSEAKT EEPTVHSSEA AIMNNSQGDG EHFAHPPSEV 240
KMHFANQSIE PLGRKVERSE TSSLPQKDLK IPGLEHASIE GPIANLSVLG TEELRQREHY 300
LKQKRDKLMS MRKDMRTKQI QNMEQKGKPT GEVEEMTEKP EMTAEEKQTL LKRRLLAEKL 360
KEEVINK 367 
Gene Ontology
  
Interpro
 IPR023379; ARF-like_2-bdp_dom. 
Pfam
 PF11527; ARL2_Bind_BART 
SMART
  
PROSITE
  
PRINTS