UniProt Accession

 PAF15_MOUSE; Q9CQX4; Q4VAG2; Q9CZ17; Q9D0A5 

Genbank Protein ID

 AY496943; AK011090; AK011645; AK011835; AK013105; AK017673; BC021413; BC096393 

Genbank Nucleotide ID

 AAR90858.1; BAB27391.1; BAB27868.1; BAB28650.1; BAB30866.1; AAH21413.1; AAH96393.1 

Protein Name

 PCNA-associated factor 

Protein Synonyms/Alias

 HCV NS5A-transactivated protein 9 homolog; PCNA-associated factor of 15 kDa; PAF15; p15PAF 

Gene Name

 Paf 

Gene Synonyms/Alias

 Ns5atp9 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	VASQAPRKVLGSSTF	acetylation	[1, 2]
24	VASQAPRKVLGSSTF	ubiquitination	[3]
45	SSRKAENKYAGGNPV	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). 

Sequence Annotation

 MOTIF 23 34 D-box.
 MOTIF 61 71 PIP-box.
 MOTIF 77 79 KEN box.
 MOTIF 84 96 Initiation motif.
 MOD_RES 71 71 Phosphoserine (By similarity).
 CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 24 24 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Cytoplasm; DNA damage; DNA repair; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; ISS:UniProtKB.
 GO:0051297; P:centrosome organization; ISS:UniProtKB.
 GO:0006260; P:DNA replication; ISS:UniProtKB.
 GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
 GO:0009411; P:response to UV; ISS:UniProtKB.
 GO:0019985; P:translesion synthesis; ISS:UniProtKB. 

Interpro

  

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PRINTS